@inproceedings{d32440995b77455ea16847edd9f28dc3,
title = "Real-time Detection of Nimodipine Effect on Ischemia Model",
abstract = "It is generally thought that neuronal damage by cerebral ischemia is associated with extracellular concentrations of the excitatory amino acids. L-glutamate over production initiated the neuronal cell death in ischemic condition. Real time quantitative measurement of glutamate would be applicable to evaluate brain injury during or after surgery, as well as to demonstrate immediate function by Nimodipine, which is one of L-type calcium channel blocker. For in-vivo glutamate measurement, the eleven vessel occlusion (11VO) was prepared by using rat model. Changes in cerebral blood flow were monitored by laser-Doppler flowmetry simultaneously with cortical glutamate level by amperometric biosensor. Ten minute ischemia was initiated by pulling the snares on the common carotid arteries (CCAs) and the external carotid arteries (ECAs) while Nimodipine was dripped on the vicinity of burr hole for CBF probe during ischemic period. In comparison with the Nimodipine-treatment and nontreatment group, peak concentration and the area under the curve (AUC) of glutamate release showed statistically significant difference between two groups. It is considered that decreased glutamate level in Nimodipine treated group is attributed to the neuroprotective effect by Nimodipine.",
keywords = "11 vessel occlusion model, Glutamate, Nimodipine, neuroprotective effect, real time monitoring",
author = "Lee, {G. J.} and Choi, {S. K.} and Eo, {Y. H.} and Lim, {J. E.} and Park, {J. H.} and Han, {J. H.} and Oh, {B. S.} and Park, {Hun Kuk}",
year = "2009",
doi = "10.1007/978-3-540-92841-6_114",
language = "English",
isbn = "9783540928409",
series = "IFMBE Proceedings",
pages = "465--467",
booktitle = "13th International Conference on Biomedical Engineering - ICBME 2008",
note = "13th International Conference on Biomedical Engineering, ICBME 2008 ; Conference date: 03-12-2008 Through 06-12-2008",
}