TY - JOUR
T1 - Recent advances on the application of nanobiomimetic structures as drug delivery systems
AU - Boraei, Seyyed Behnam Abdollahi
AU - Javadpour, Sadaf
AU - Nejad, Fatemeh Kamali
AU - Otaghvari, Farnaz Hosseinzadeh
AU - Zare, Yasser
AU - Rhee, Kyong Yop
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/10
Y1 - 2024/10
N2 - Nanobiomimetic structures are currently emerging as a technology with considerable potential in the field of drug delivery systems. These structures, which take inspiration from nature, hold the potential to completely transform the treatment of diseases by facilitating drug delivery that is highly precise and target-oriented. In this comprehensive review, we place significant emphasis on examining the distinctive physicochemical properties possessed by nanobiomimetic structures, including but not limited to their hydrophilicity, particle shape, surface charge, composition, and concentration, all of which collectively contribute to their overall functionality. Additionally, we undertake a thorough exploration of the utilization of specific ligands that are strategically placed on the surface of these carriers, effectively enhancing their specificity towards target cells. Furthermore, we engage in a discussion surrounding innovative strategies that have been devised to improve the drug loading capacity, cellular uptake, and sustained release of drugs in target cells, all accomplished through the utilization of nanobiomimetic carriers. Furthermore, we seize the opportunity to explore the methods by which biomimetic approaches can effectively enhance drug efficiency and targeting, ultimately leading to a significant enhancement in the effectiveness of drugs within targeted drug delivery systems. Finally, we must highlight that this study serves to underscore the immense potential that nanobiomimetic drug carriers possess in terms of completely transforming the landscape of drug delivery.
AB - Nanobiomimetic structures are currently emerging as a technology with considerable potential in the field of drug delivery systems. These structures, which take inspiration from nature, hold the potential to completely transform the treatment of diseases by facilitating drug delivery that is highly precise and target-oriented. In this comprehensive review, we place significant emphasis on examining the distinctive physicochemical properties possessed by nanobiomimetic structures, including but not limited to their hydrophilicity, particle shape, surface charge, composition, and concentration, all of which collectively contribute to their overall functionality. Additionally, we undertake a thorough exploration of the utilization of specific ligands that are strategically placed on the surface of these carriers, effectively enhancing their specificity towards target cells. Furthermore, we engage in a discussion surrounding innovative strategies that have been devised to improve the drug loading capacity, cellular uptake, and sustained release of drugs in target cells, all accomplished through the utilization of nanobiomimetic carriers. Furthermore, we seize the opportunity to explore the methods by which biomimetic approaches can effectively enhance drug efficiency and targeting, ultimately leading to a significant enhancement in the effectiveness of drugs within targeted drug delivery systems. Finally, we must highlight that this study serves to underscore the immense potential that nanobiomimetic drug carriers possess in terms of completely transforming the landscape of drug delivery.
KW - Drug efficacy
KW - Nanobiomimetic
KW - Nanocarriers
KW - Targeted drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85201387292&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2024.106009
DO - 10.1016/j.jddst.2024.106009
M3 - Review article
AN - SCOPUS:85201387292
SN - 1773-2247
VL - 100
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 106009
ER -