Recurrent cytogenetic abnormalities in acute myeloid leukemia

John J. Yang, Tae Sung Park, Thomas S.K. Wan

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The spectrum of chromosomal abnormality associated with leukemogenesis of acute myeloid leukemia (AML) is broad and heterogeneous when compared to chronic myeloid leukemia and other myeloid neoplasms. Recurrent chromosomal translocations such as t(8;21), t(15;17), and inv(16) are frequently detected, but hundreds of other uncommon chromosomal aberrations from AML also exist. This chapter discusses 22 chromosomal abnormalities that are common structural, numerical aberrations, and other important but infrequent (less than 1 %) translocations emphasized in the WHO classification. Brief morphologic, cytogenetic, and clinical characteristics are summarized, so as to provide a concise reference to cancer cytogenetic laboratories. Morphology based on FAB classification is used together with the current WHO classification due to frequent mentioning in a vast number of reference literatures. Characteristic chromosomal aberrations of other myeloid neoplasms such as myelodysplastic syndrome and myeloproliferative neoplasm will be discussed in separate chapters—except for certain abnormalities such as t(9;22) in de novo AML. Gene mutations detected in normal karyotype AML by cutting edge next generation sequencing technology are also briefly mentioned.

Original languageEnglish
Pages (from-to)223-245
Number of pages23
JournalMethods in Molecular Biology
Volume1541
DOIs
Publication statusPublished - 2017

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media LLC 2017.

Keywords

  • Acute myeloid leukemia
  • Chromosomal abnormality
  • Leukemogenesis
  • WHO classification

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