Abstract
Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling. Here, we demonstrate that TRIM25 is required for melanoma differentiation-associated gene 5 (MDA5) and MAVS mediated activation of NF-κB and interferon production. TRIM25 is required for the full activation of NF-κB at the downstream of MAVS, while it is not involved in IRF3 nuclear translocation. Mechanical studies showed that TRIM25 is involved in TRAF6-mediated NF-κB activation. These collectively indicate that TRIM25 plays an additional role in RIG-I/MDA5 signaling other than RIG-I ubiquitination via activation of NF-κB.
Original language | English |
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Pages (from-to) | 756-764 |
Number of pages | 9 |
Journal | Molecules and Cells |
Volume | 38 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2015 |
Bibliographical note
Publisher Copyright:© The Korean Society for Molecular and Cellular Biology.
Keywords
- MAVS
- MDA5
- NF-κB
- TRAF6
- TRIM25