Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice

Soyoung Han; Jong Ryoul Choi; Ki Soon Shin; Shin Jung Kang

doi:10.1016/j.brainres.2012.09.022

Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice

Soyoung Han, Jong Ryoul Choi, Ki Soon Shin, Shin Jung Kang

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73 Citations (Scopus)

Abstract

In the present study, we investigated whether resveratrol, a SIRT1 activator, can suppress the motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Chronic intraperitoneal injection of resveratrol delayed the disease onset and extended survival of the transgenic mice overexpressing G93A-SOD1. The number of surviving motor neurons increased in the resveratrol-injected G93A mice. Importantly, the levels of Hsp25 and Hsp70 were elevated while the level of heat shock factor 1 (HSF1) acetylation decreased in the spinal cords of the resveratrol-injected G93A mice. Our data suggest that resveratrol may protect motor neurons from the mutant SOD1-induced neurotoxicity by promoting SIRT1-mediated deacetylation of HSF1 and subsequent upregulation of Hsps.

Original language	English
Pages (from-to)	112-117
Number of pages	6
Journal	Brain Research
Volume	1483
DOIs	https://doi.org/10.1016/j.brainres.2012.09.022
Publication status	Published - 5 Nov 2012

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation of Korea ( 2009-0068713 and 2009-0075097 ).

Keywords

Amyotrophic lateral sclerosis
Heat shock factor 1
Heat shock protein
Resveratrol
SIRT1
Superoxide dismutase 1

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10.1016/j.brainres.2012.09.022

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title = "Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice",

abstract = "In the present study, we investigated whether resveratrol, a SIRT1 activator, can suppress the motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Chronic intraperitoneal injection of resveratrol delayed the disease onset and extended survival of the transgenic mice overexpressing G93A-SOD1. The number of surviving motor neurons increased in the resveratrol-injected G93A mice. Importantly, the levels of Hsp25 and Hsp70 were elevated while the level of heat shock factor 1 (HSF1) acetylation decreased in the spinal cords of the resveratrol-injected G93A mice. Our data suggest that resveratrol may protect motor neurons from the mutant SOD1-induced neurotoxicity by promoting SIRT1-mediated deacetylation of HSF1 and subsequent upregulation of Hsps.",

keywords = "Amyotrophic lateral sclerosis, Heat shock factor 1, Heat shock protein, Resveratrol, SIRT1, Superoxide dismutase 1",

author = "Soyoung Han and Choi, {Jong Ryoul} and {Soon Shin}, Ki and Kang, {Shin Jung}",

note = "Funding Information: This work was supported by grants from the National Research Foundation of Korea ( 2009-0068713 and 2009-0075097 ).",

year = "2012",

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doi = "10.1016/j.brainres.2012.09.022",

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AU - Han, Soyoung

AU - Choi, Jong Ryoul

AU - Soon Shin, Ki

AU - Kang, Shin Jung

N1 - Funding Information: This work was supported by grants from the National Research Foundation of Korea ( 2009-0068713 and 2009-0075097 ).

PY - 2012/11/5

Y1 - 2012/11/5

N2 - In the present study, we investigated whether resveratrol, a SIRT1 activator, can suppress the motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Chronic intraperitoneal injection of resveratrol delayed the disease onset and extended survival of the transgenic mice overexpressing G93A-SOD1. The number of surviving motor neurons increased in the resveratrol-injected G93A mice. Importantly, the levels of Hsp25 and Hsp70 were elevated while the level of heat shock factor 1 (HSF1) acetylation decreased in the spinal cords of the resveratrol-injected G93A mice. Our data suggest that resveratrol may protect motor neurons from the mutant SOD1-induced neurotoxicity by promoting SIRT1-mediated deacetylation of HSF1 and subsequent upregulation of Hsps.

AB - In the present study, we investigated whether resveratrol, a SIRT1 activator, can suppress the motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Chronic intraperitoneal injection of resveratrol delayed the disease onset and extended survival of the transgenic mice overexpressing G93A-SOD1. The number of surviving motor neurons increased in the resveratrol-injected G93A mice. Importantly, the levels of Hsp25 and Hsp70 were elevated while the level of heat shock factor 1 (HSF1) acetylation decreased in the spinal cords of the resveratrol-injected G93A mice. Our data suggest that resveratrol may protect motor neurons from the mutant SOD1-induced neurotoxicity by promoting SIRT1-mediated deacetylation of HSF1 and subsequent upregulation of Hsps.

KW - Amyotrophic lateral sclerosis

KW - Heat shock factor 1

KW - Heat shock protein

KW - Resveratrol

KW - SIRT1

KW - Superoxide dismutase 1

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DO - 10.1016/j.brainres.2012.09.022

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AN - SCOPUS:84867581334

SN - 0006-8993

VL - 1483

SP - 112

EP - 117

JO - Brain Research

JF - Brain Research

ER -

Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice

Abstract

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Keywords

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