TY - JOUR
T1 - Retraction Note
T2 - Fluoxetine induces apoptosis through endoplasmic reticulum stress via mitogen-activated protein kinase activation and histone hyperacetylation in SK-N-BE(2)-M17 human neuroblastoma cells
AU - Choi, Ji Hyun
AU - Jeong, Yeon Ju
AU - Yu, Ah Ran
AU - Yoon, Kyung Sik
AU - Choe, Wonchae
AU - Ha, Joohun
AU - Kim, Sung Soo
AU - Yeo, Eui Ju
AU - Kang, Insug
N1 - Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2022.
PY - 2022/12
Y1 - 2022/12
N2 - The Editors-in-Chief have retracted this article because there are errors and duplications in some of the figures: In Fig. 2 A the ATF6α(p90) line appears to have been spliced. The β-actin row in Fig. 2 F has been duplicated in the β-actin lines of Figs. 3E and 4 C and 4 F. Figure 2 F supports the conclusion that FLX and TG induce cell death by CHOP. However, in light of the duplication of the β-actin row this conclusion cannot stand and validity of this article is severely undermined. In Fig. 4 C, cells were pre-treated with ASK1 inhibitor 5 μM NQDI-1 followed by treatment with FLX for 24 h. As the western blot does not contain a valid household gene control, the conclusion that the inhibition of ASK1 significantly blocked FLX-induced cell death, CHOP expression, and caspase-4 cleavage, cannot be made. The duplication of the β-actin row also means that Fig. 4 F is missing the control. Therefore, the conclusion that inhibition of ASK1 by NQDI-1 and ASK1 siRNA transfection reduced phosphorylation of p38, JNK, and ERK, cannot be made. The conclusions of this article are therefore unreliable. A written response from Dr. Insug Kang and Dr. Eui-Ju Yeo, representing all authors, confirmed that there were mistakes and errors in the article. Drs. Kang and Yeo expressed that they do not agree to this retraction.
AB - The Editors-in-Chief have retracted this article because there are errors and duplications in some of the figures: In Fig. 2 A the ATF6α(p90) line appears to have been spliced. The β-actin row in Fig. 2 F has been duplicated in the β-actin lines of Figs. 3E and 4 C and 4 F. Figure 2 F supports the conclusion that FLX and TG induce cell death by CHOP. However, in light of the duplication of the β-actin row this conclusion cannot stand and validity of this article is severely undermined. In Fig. 4 C, cells were pre-treated with ASK1 inhibitor 5 μM NQDI-1 followed by treatment with FLX for 24 h. As the western blot does not contain a valid household gene control, the conclusion that the inhibition of ASK1 significantly blocked FLX-induced cell death, CHOP expression, and caspase-4 cleavage, cannot be made. The duplication of the β-actin row also means that Fig. 4 F is missing the control. Therefore, the conclusion that inhibition of ASK1 by NQDI-1 and ASK1 siRNA transfection reduced phosphorylation of p38, JNK, and ERK, cannot be made. The conclusions of this article are therefore unreliable. A written response from Dr. Insug Kang and Dr. Eui-Ju Yeo, representing all authors, confirmed that there were mistakes and errors in the article. Drs. Kang and Yeo expressed that they do not agree to this retraction.
UR - http://www.scopus.com/inward/record.url?scp=85139260909&partnerID=8YFLogxK
U2 - 10.1007/s10495-022-01772-7
DO - 10.1007/s10495-022-01772-7
M3 - Comment/debate
C2 - 36180606
AN - SCOPUS:85139260909
SN - 1360-8185
VL - 27
SP - 1061
JO - Apoptosis : an international journal on programmed cell death
JF - Apoptosis : an international journal on programmed cell death
IS - 11-12
ER -