Retraction Note: Fluoxetine induces apoptosis through endoplasmic reticulum stress via mitogen-activated protein kinase activation and histone hyperacetylation in SK-N-BE(2)-M17 human neuroblastoma cells

Ji Hyun Choi, Yeon Ju Jeong, Ah Ran Yu, Kyung Sik Yoon, Wonchae Choe, Joohun Ha, Sung Soo Kim, Eui Ju Yeo, Insug Kang

Research output: Contribution to journalComment/debate

Abstract

The Editors-in-Chief have retracted this article because there are errors and duplications in some of the figures: In Fig. 2 A the ATF6α(p90) line appears to have been spliced. The β-actin row in Fig. 2 F has been duplicated in the β-actin lines of Figs. 3E and 4 C and 4 F. Figure 2 F supports the conclusion that FLX and TG induce cell death by CHOP. However, in light of the duplication of the β-actin row this conclusion cannot stand and validity of this article is severely undermined. In Fig. 4 C, cells were pre-treated with ASK1 inhibitor 5 μM NQDI-1 followed by treatment with FLX for 24 h. As the western blot does not contain a valid household gene control, the conclusion that the inhibition of ASK1 significantly blocked FLX-induced cell death, CHOP expression, and caspase-4 cleavage, cannot be made. The duplication of the β-actin row also means that Fig. 4 F is missing the control. Therefore, the conclusion that inhibition of ASK1 by NQDI-1 and ASK1 siRNA transfection reduced phosphorylation of p38, JNK, and ERK, cannot be made. The conclusions of this article are therefore unreliable. A written response from Dr. Insug Kang and Dr. Eui-Ju Yeo, representing all authors, confirmed that there were mistakes and errors in the article. Drs. Kang and Yeo expressed that they do not agree to this retraction.

Original languageEnglish
Pages (from-to)1061
Number of pages1
JournalApoptosis : an international journal on programmed cell death
Volume27
Issue number11-12
DOIs
Publication statusPublished - Dec 2022

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© Springer Science+Business Media, LLC, part of Springer Nature 2022.

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