Abstract
We investigated the effects of the aqueous extract of Salviae radix root (SRRAE) on immediate allergic reactions. SRRAE inhibited by 72.7% passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) immunoglobulin E (IgE). SRRAE dose dependently inhibited histamine release and tumor necrosis factor-α production from the rat peritoneal mast cells (RPMCs) by anti-DNP IgE. However, SRRAE showed no significant inhibitory effect on compound 48/80-induced systemic allergic reaction and histamine release from RPMCs. The level of cAMP in RPMCs, when SRRAE was added, significantly increased compared with that of a normal control. These results indicate that SRRAE may contain compounds with actions that inhibit anti-DNP IgE-induced mast cell degranulation in rats. Copyright (C) 1999 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 603-608 |
| Number of pages | 6 |
| Journal | General Pharmacology: The Vascular System |
| Volume | 32 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 1999 |
Bibliographical note
Funding Information:This study was supported by Wonkwang University in 1997.
Keywords
- Anti-dinitrophenyl IgE
- Compound 48/80
- Histamine
- Immediate allergic reaction
- Salviae radix
- cAMP
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