TY - JOUR
T1 - Saponins Derived from the Korean Endemic Plant Heloniopsis koreana Inhibit Diffuse-type Gastric Cancer Cells
AU - Cho, Su Yeon
AU - Kim, Yejin
AU - Hwang, Hoseong
AU - Kwon, Yujin
AU - Son, So Ri
AU - Baek, Jong Gwon
AU - Park, In Wha
AU - Kang, Yoon Jin
AU - Rhee, Hyungjin
AU - Kwon, Hak Cheol
AU - Kwon, Jaeyoung
AU - Kim, Won Kyu
AU - Jang, Dae Sik
N1 - Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society
PY - 2023/12/19
Y1 - 2023/12/19
N2 - Diffuse-type gastric cancer (GC) is a type of stomach cancer that occurs in small clusters of cells that are widely spread. It does not typically manifest with symptoms until the advanced stages and often goes undetected in routine imaging tests. In addition, there is no specific targeted therapy for diffuse-type GC and it has a high mortality risk. Hence, it is worthwhile to discover molecules against this cancer. In this study, the extract of Heloniopsis koreana, which is endemic to Korea, exhibited cytotoxicity against two diffuse-type GC cell lines, MKN1 and SNU668. This led to the isolation of 10 compounds, including a new cinnamic acid glycoside. Of the compounds, saponin Th (4) and SNF 11 (5) showed potent activities with IC50 values of 3.66 and 3.85 μM, respectively, in MKN1 cells, and 1.8 and 1.98 μM, respectively, in SNU668 cells. These compounds prevented cancer cell division, invasion, and colony formation in both cell lines. In addition, these compounds induced cancer cell death through conventional cell death pathways, showing an increase in ADP-ribose polymerase, caspase 3, and BAX and a decrease in BCL2.
AB - Diffuse-type gastric cancer (GC) is a type of stomach cancer that occurs in small clusters of cells that are widely spread. It does not typically manifest with symptoms until the advanced stages and often goes undetected in routine imaging tests. In addition, there is no specific targeted therapy for diffuse-type GC and it has a high mortality risk. Hence, it is worthwhile to discover molecules against this cancer. In this study, the extract of Heloniopsis koreana, which is endemic to Korea, exhibited cytotoxicity against two diffuse-type GC cell lines, MKN1 and SNU668. This led to the isolation of 10 compounds, including a new cinnamic acid glycoside. Of the compounds, saponin Th (4) and SNF 11 (5) showed potent activities with IC50 values of 3.66 and 3.85 μM, respectively, in MKN1 cells, and 1.8 and 1.98 μM, respectively, in SNU668 cells. These compounds prevented cancer cell division, invasion, and colony formation in both cell lines. In addition, these compounds induced cancer cell death through conventional cell death pathways, showing an increase in ADP-ribose polymerase, caspase 3, and BAX and a decrease in BCL2.
UR - http://www.scopus.com/inward/record.url?scp=85180091788&partnerID=8YFLogxK
U2 - 10.1021/acsomega.3c06714
DO - 10.1021/acsomega.3c06714
M3 - Article
AN - SCOPUS:85180091788
SN - 2470-1343
VL - 8
SP - 48019
EP - 48027
JO - ACS Omega
JF - ACS Omega
IS - 50
ER -
