Schisandra chinensis and Its Main Constituent Schizandrin Attenuate Allergic Reactions by Down-Regulating Caspase-1 in Ovalbumin-Sensitized Mice

Na Ra Han, Phil Dong Moon, Na Rae Kim, Hee Yun Kim, Hyun Ja Jeong, Hyung Min Kim

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Schisandra chinensis (SC) and its main constituent, schizandrin (SCH) exhibit anti-inflammatory and anti-allergic activities. Allergic and inflammatory reactions are aggravated via caspase-1 signaling pathway. However, the regulatory effects of SC and SCH on caspase-1 activation have not been clarified yet. In this study, we aimed to clarify the anti-allergic effects of SC and SCH using an ovalbumin (OVA)-sensitized mice and anti-CD3 and anti-CD28 antibodies-stimulated splenocytes. SC or SCH significantly inhibited the levels of immunoglobulin (Ig)E, IgG1, or interleukin (IL)-4 in serum of OVA-sensitized mice. SC or SCH significantly inhibited the levels of IL-6, tumor necrosis factor (TNF)-α, and IL-1β in spleen of the OVA-sensitized mice. SC or SCH significantly suppressed the expression of caspase-1 and receptor-interacting protein (RIP)-2 in spleen of the OVA-sensitized mice. In activated splenocytes, SC or SCH significantly decreased the expression of caspase-1 and RIP-2 as well as the production of IL-6 and TNF-α. We suggest that SC and SCH exert an anti-allergic effect by down-regulating caspase-1 signaling.

Original languageEnglish
Pages (from-to)159-172
Number of pages14
JournalAmerican Journal of Chinese Medicine
Volume45
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • Allergic Reaction
  • Caspase-1
  • Schisandra chinensis
  • Schizandrin
  • Splenocytes

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