Shiquandabutangjiaweibang inhibits tumor metastasis and angiogenesis via regulation of topoisomerase-1

Sung Hoon Kim; Tae Hyung Lee; Deok Chun Yang; Hyung Min Kim; Jeung Beum Kim; Mi Kyung Park; Yong Soo Bae

doi:10.1016/j.jep.2005.01.010

Shiquandabutangjiaweibang inhibits tumor metastasis and angiogenesis via regulation of topoisomerase-1

Sung Hoon Kim
, Tae Hyung Lee
, Deok Chun Yang
, Hyung Min Kim
, Jeung Beum Kim
, Mi Kyung Park
, Yong Soo Bae

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Shiquandabutangjiaweibang (SDJ) is a traditional medicine prescription used for increasing body resistance against cancer. In the present study, the effect of SDJ extract on tumor metastasis and angiogenesis was evaluated. SDJ showed cytotoxicity against P388 (leukemia cells) and B16-F10 (murine melanoma cells) to 60% of control at 1 mg. SDJ significantly inhibited lung metastasis and also restored the number of platelets in C57BL/6 mice with thrombocytopenia induced by intravenous injection of B16-F10 cells. SDJ significantly disrupted chick embryonic angiogenesis in the chorioallantoic membrane (CAM). Interestingly, SDJ suppressed DNA topoisomerase I in a concentration-dependent manner. These results suggest that SDJ can be a potent inhibitor of metastasis and angiogenesis, at least in part, via regulation of topoisomerase I.

Original language	English
Pages (from-to)	157-162
Number of pages	6
Journal	Journal of Ethnopharmacology
Volume	98
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jep.2005.01.010
Publication status	Published - 8 Apr 2005

Bibliographical note

Funding Information:
This study was supported by the research grants of Ministry of Health and Welfare (01-PJ9-PG1-01CO05-0004) and Agricultural R&D Promotion Center.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angiogenesis
CAM
Metastasis
Shiquandabutangjiaweibang (SDJ)
Topoisomerase I

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10.1016/j.jep.2005.01.010

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title = "Shiquandabutangjiaweibang inhibits tumor metastasis and angiogenesis via regulation of topoisomerase-1",

abstract = "Shiquandabutangjiaweibang (SDJ) is a traditional medicine prescription used for increasing body resistance against cancer. In the present study, the effect of SDJ extract on tumor metastasis and angiogenesis was evaluated. SDJ showed cytotoxicity against P388 (leukemia cells) and B16-F10 (murine melanoma cells) to 60\% of control at 1 mg. SDJ significantly inhibited lung metastasis and also restored the number of platelets in C57BL/6 mice with thrombocytopenia induced by intravenous injection of B16-F10 cells. SDJ significantly disrupted chick embryonic angiogenesis in the chorioallantoic membrane (CAM). Interestingly, SDJ suppressed DNA topoisomerase I in a concentration-dependent manner. These results suggest that SDJ can be a potent inhibitor of metastasis and angiogenesis, at least in part, via regulation of topoisomerase I.",

keywords = "Angiogenesis, CAM, Metastasis, Shiquandabutangjiaweibang (SDJ), Topoisomerase I",

author = "Kim, \{Sung Hoon\} and Lee, \{Tae Hyung\} and Yang, \{Deok Chun\} and Kim, \{Hyung Min\} and Kim, \{Jeung Beum\} and Park, \{Mi Kyung\} and Bae, \{Yong Soo\}",

note = "Funding Information: This study was supported by the research grants of Ministry of Health and Welfare (01-PJ9-PG1-01CO05-0004) and Agricultural R\&D Promotion Center. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2005",

month = apr,

day = "8",

doi = "10.1016/j.jep.2005.01.010",

language = "English",

volume = "98",

pages = "157--162",

journal = "Journal of Ethnopharmacology",

issn = "0378-8741",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Shiquandabutangjiaweibang inhibits tumor metastasis and angiogenesis via regulation of topoisomerase-1

AU - Kim, Sung Hoon

AU - Lee, Tae Hyung

AU - Yang, Deok Chun

AU - Kim, Hyung Min

AU - Kim, Jeung Beum

AU - Park, Mi Kyung

AU - Bae, Yong Soo

N1 - Funding Information: This study was supported by the research grants of Ministry of Health and Welfare (01-PJ9-PG1-01CO05-0004) and Agricultural R&D Promotion Center. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2005/4/8

Y1 - 2005/4/8

N2 - Shiquandabutangjiaweibang (SDJ) is a traditional medicine prescription used for increasing body resistance against cancer. In the present study, the effect of SDJ extract on tumor metastasis and angiogenesis was evaluated. SDJ showed cytotoxicity against P388 (leukemia cells) and B16-F10 (murine melanoma cells) to 60% of control at 1 mg. SDJ significantly inhibited lung metastasis and also restored the number of platelets in C57BL/6 mice with thrombocytopenia induced by intravenous injection of B16-F10 cells. SDJ significantly disrupted chick embryonic angiogenesis in the chorioallantoic membrane (CAM). Interestingly, SDJ suppressed DNA topoisomerase I in a concentration-dependent manner. These results suggest that SDJ can be a potent inhibitor of metastasis and angiogenesis, at least in part, via regulation of topoisomerase I.

AB - Shiquandabutangjiaweibang (SDJ) is a traditional medicine prescription used for increasing body resistance against cancer. In the present study, the effect of SDJ extract on tumor metastasis and angiogenesis was evaluated. SDJ showed cytotoxicity against P388 (leukemia cells) and B16-F10 (murine melanoma cells) to 60% of control at 1 mg. SDJ significantly inhibited lung metastasis and also restored the number of platelets in C57BL/6 mice with thrombocytopenia induced by intravenous injection of B16-F10 cells. SDJ significantly disrupted chick embryonic angiogenesis in the chorioallantoic membrane (CAM). Interestingly, SDJ suppressed DNA topoisomerase I in a concentration-dependent manner. These results suggest that SDJ can be a potent inhibitor of metastasis and angiogenesis, at least in part, via regulation of topoisomerase I.

KW - Angiogenesis

KW - CAM

KW - Metastasis

KW - Shiquandabutangjiaweibang (SDJ)

KW - Topoisomerase I

UR - https://www.scopus.com/pages/publications/14844311289

U2 - 10.1016/j.jep.2005.01.010

DO - 10.1016/j.jep.2005.01.010

M3 - Article

C2 - 15763377

AN - SCOPUS:14844311289

SN - 0378-8741

VL - 98

SP - 157

EP - 162

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 1-2

ER -

Shiquandabutangjiaweibang inhibits tumor metastasis and angiogenesis via regulation of topoisomerase-1

Abstract

Bibliographical note

UN SDGs

Keywords

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