Standardized Herbal Formula PM012 Decreases Cognitive Impairment and Promotes Neurogenesis in the 3xTg AD Mouse Model of Alzheimer’s Disease

Minsook Ye; Hwan Suck Chung; Yong Ho An; Su jin Lim; Won Choi; A. Ram Yu; Jin Su Kim; Manho Kang; Seunghun Cho; Insop Shim; Hyunsu Bae

doi:10.1007/s12035-015-9458-x

Standardized Herbal Formula PM012 Decreases Cognitive Impairment and Promotes Neurogenesis in the 3xTg AD Mouse Model of Alzheimer’s Disease

Minsook Ye, Hwan Suck Chung, Yong Ho An, Su jin Lim, Won Choi, A. Ram Yu, Jin Su Kim, Manho Kang, Seunghun Cho, Insop Shim, Hyunsu Bae

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19 Citations (Scopus)

Abstract

Alzheimer’s disease (AD) is a severe neurodegenerative disease for which there is currently no effective treatment. This study investigated whether treatment with the herbal formula PM012 would improve the cognitive function and the pathological features of AD in 3xTg-AD mice. The cognitive function of 3xTg-AD mice was assessed using the Morris water maze test and positron-emission tomography (PET) with 18 F-2 fluoro-2-deoxy-D-glucose ([F-18] FDG) neuroimaging. The levels of the amyloid beta (Aβ) deposits in the hippocampus were evaluated by immunohistochemistry. Neurogenesis was assessed by quantitative labeling with the DNA marker bromodeoxyuridine (BrdU) and the newborn neuron marker doublecortin (DCX). PM012 treatment significantly ameliorated memory deficit in AD mice, as shown by shortened escape latencies and increased time spent in the target zone during probe tests. In addition, PM012 significantly decreased Aβ deposits, up-regulated the expression of brain-derived neurotrophic factor (BDNF), increased neurogenesis, and improved brain glucose metabolism in the 3xTg-AD mice. These results suggest that PM012 could be a promising treatment for AD.

Original language	English
Pages (from-to)	5401-5412
Number of pages	12
Journal	Molecular Neurobiology
Volume	53
Issue number	8
DOIs	https://doi.org/10.1007/s12035-015-9458-x
Publication status	Published - 1 Oct 2016

Bibliographical note

Publisher Copyright:
© 2015, Springer Science+Business Media New York.

Keywords

3xTg AD
Alzheimer’s disease
Beta-amyloid
Neurogenesis
PET
PM012

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10.1007/s12035-015-9458-x

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title = "Standardized Herbal Formula PM012 Decreases Cognitive Impairment and Promotes Neurogenesis in the 3xTg AD Mouse Model of Alzheimer{\textquoteright}s Disease",

abstract = "Alzheimer{\textquoteright}s disease (AD) is a severe neurodegenerative disease for which there is currently no effective treatment. This study investigated whether treatment with the herbal formula PM012 would improve the cognitive function and the pathological features of AD in 3xTg-AD mice. The cognitive function of 3xTg-AD mice was assessed using the Morris water maze test and positron-emission tomography (PET) with 18 F-2 fluoro-2-deoxy-D-glucose ([F-18] FDG) neuroimaging. The levels of the amyloid beta (Aβ) deposits in the hippocampus were evaluated by immunohistochemistry. Neurogenesis was assessed by quantitative labeling with the DNA marker bromodeoxyuridine (BrdU) and the newborn neuron marker doublecortin (DCX). PM012 treatment significantly ameliorated memory deficit in AD mice, as shown by shortened escape latencies and increased time spent in the target zone during probe tests. In addition, PM012 significantly decreased Aβ deposits, up-regulated the expression of brain-derived neurotrophic factor (BDNF), increased neurogenesis, and improved brain glucose metabolism in the 3xTg-AD mice. These results suggest that PM012 could be a promising treatment for AD.",

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AU - Lim, Su jin

AU - Choi, Won

AU - Yu, A. Ram

AU - Kim, Jin Su

AU - Kang, Manho

AU - Cho, Seunghun

AU - Shim, Insop

AU - Bae, Hyunsu

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Standardized Herbal Formula PM012 Decreases Cognitive Impairment and Promotes Neurogenesis in the 3xTg AD Mouse Model of Alzheimer’s Disease

Abstract

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Keywords

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