Surface modification of hydroxyapatite nanocrystals by grafting polymers containing phosphonic acid groups

Hyung Woo Choi; Hong Jae Lee; Kyung Ja Kim; Hyun Min Kim; Sang Cheon Lee

doi:10.1016/j.jcis.2006.05.069

Surface modification of hydroxyapatite nanocrystals by grafting polymers containing phosphonic acid groups

Hyung Woo Choi, Hong Jae Lee, Kyung Ja Kim, Hyun Min Kim, Sang Cheon Lee

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

Abstract

A novel approach for the surface modification of hydroxyapatite (HAp) nanocrystals is described by grafting polymerization of vinyl phosphonic acid (VPA) using a redox initiating system in an aqueous media. Fourier transform infrared (FT-IR) and XRD analyses confirmed the modification reaction on HAp surfaces. Inductively coupled plasma mass spectroscopy (ICP MS) showed that the Ca/P molar ratio decreased from 1.67 to 1.36 with increasing the feed VPA amount. Zeta potentials of unmodified HAp and modified HAp in phosphate-buffered saline (PBS) solutions (pH 7.4, ionic strength = 10 mM) were negative and decreased with increasing the amount of grafted PVPA. Transmission electron microscopy (TEM) measurements and time-dependent phase monitoring indicated that the colloidal stability of modified HAp over unmodified HAp in water dramatically increased and tended to exist as single nanocrystals without aggregation.

Original language	English
Pages (from-to)	277-281
Number of pages	5
Journal	Journal of Colloid and Interface Science
Volume	304
Issue number	1
DOIs	https://doi.org/10.1016/j.jcis.2006.05.069
Publication status	Published - 1 Dec 2006

Bibliographical note

Funding Information:
This research was supported by a grant (06K1501-01510) from the Center for Nanostructured Materials Technology under the 21st Century Frontier R&D Programs of the Ministry of Science and Technology, Korea. The authors thank Chiyoung Park of Inha University for invaluable discussion and technical assistance.

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

Colloidal stability
Grafting
Hydroxyapatite
Phosphonic acid
Surface modification

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abstract = "A novel approach for the surface modification of hydroxyapatite (HAp) nanocrystals is described by grafting polymerization of vinyl phosphonic acid (VPA) using a redox initiating system in an aqueous media. Fourier transform infrared (FT-IR) and XRD analyses confirmed the modification reaction on HAp surfaces. Inductively coupled plasma mass spectroscopy (ICP MS) showed that the Ca/P molar ratio decreased from 1.67 to 1.36 with increasing the feed VPA amount. Zeta potentials of unmodified HAp and modified HAp in phosphate-buffered saline (PBS) solutions (pH 7.4, ionic strength = 10 mM) were negative and decreased with increasing the amount of grafted PVPA. Transmission electron microscopy (TEM) measurements and time-dependent phase monitoring indicated that the colloidal stability of modified HAp over unmodified HAp in water dramatically increased and tended to exist as single nanocrystals without aggregation.",

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doi = "10.1016/j.jcis.2006.05.069",

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AU - Kim, Hyun Min

AU - Lee, Sang Cheon

N1 - Funding Information: This research was supported by a grant (06K1501-01510) from the Center for Nanostructured Materials Technology under the 21st Century Frontier R&D Programs of the Ministry of Science and Technology, Korea. The authors thank Chiyoung Park of Inha University for invaluable discussion and technical assistance. Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2006/12/1

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N2 - A novel approach for the surface modification of hydroxyapatite (HAp) nanocrystals is described by grafting polymerization of vinyl phosphonic acid (VPA) using a redox initiating system in an aqueous media. Fourier transform infrared (FT-IR) and XRD analyses confirmed the modification reaction on HAp surfaces. Inductively coupled plasma mass spectroscopy (ICP MS) showed that the Ca/P molar ratio decreased from 1.67 to 1.36 with increasing the feed VPA amount. Zeta potentials of unmodified HAp and modified HAp in phosphate-buffered saline (PBS) solutions (pH 7.4, ionic strength = 10 mM) were negative and decreased with increasing the amount of grafted PVPA. Transmission electron microscopy (TEM) measurements and time-dependent phase monitoring indicated that the colloidal stability of modified HAp over unmodified HAp in water dramatically increased and tended to exist as single nanocrystals without aggregation.

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Surface modification of hydroxyapatite nanocrystals by grafting polymers containing phosphonic acid groups

Abstract

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