Synthesis and Cytotoxicity of Dendritic Platinum Nanoparticles with HEK-293 Cells

Kyubin Shim; Jeonghun Kim; Yoon Uk Heo; Bo Jiang; Cuiling Li; Mohammed Shahabuddin; Kevin C.W. Wu; Md Shahriar A. Hossain; Yusuke Yamauchi; Jung Ho Kim

doi:10.1002/asia.201601239

Synthesis and Cytotoxicity of Dendritic Platinum Nanoparticles with HEK-293 Cells

Kyubin Shim
, Jeonghun Kim
, Yoon Uk Heo
, Bo Jiang
, Cuiling Li
, Mohammed Shahabuddin
, Kevin C.W. Wu
, Md Shahriar A. Hossain
, Yusuke Yamauchi
, Jung Ho Kim

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Dendritic platinum nanoparticles (DPNs) have been synthesized from l-ascorbic acid and an amphiphilic non-ionic surfactant (Brij-58) via a sonochemical method. The particle size and shape of the DPNs could be tuned by changing the reduction temperature, resulting in a uniform DPN with a size of 23 nm or 60 nm. The facets of DPNs have been studied by high-resolution transmission electron microscopy. The cytotoxicity of DPNs has been investigated using human embryonic kidney cells (HEK-293), and the biological adaptability exhibited by DPNs has opened a pathway to biomedical applications such as drug-delivery systems, photothermal treatment, and biosensors.

Original language	English
Pages (from-to)	21-26
Number of pages	6
Journal	Chemistry - An Asian Journal
Volume	12
Issue number	1
DOIs	https://doi.org/10.1002/asia.201601239
Publication status	Published - 3 Jan 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

biocompatibility
cytotoxicity
nanoparticles
nanoporous materials
platinum

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10.1002/asia.201601239

Cite this

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title = "Synthesis and Cytotoxicity of Dendritic Platinum Nanoparticles with HEK-293 Cells",

abstract = "Dendritic platinum nanoparticles (DPNs) have been synthesized from l-ascorbic acid and an amphiphilic non-ionic surfactant (Brij-58) via a sonochemical method. The particle size and shape of the DPNs could be tuned by changing the reduction temperature, resulting in a uniform DPN with a size of 23 nm or 60 nm. The facets of DPNs have been studied by high-resolution transmission electron microscopy. The cytotoxicity of DPNs has been investigated using human embryonic kidney cells (HEK-293), and the biological adaptability exhibited by DPNs has opened a pathway to biomedical applications such as drug-delivery systems, photothermal treatment, and biosensors.",

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doi = "10.1002/asia.201601239",

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AU - Shim, Kyubin

AU - Kim, Jeonghun

AU - Heo, Yoon Uk

AU - Jiang, Bo

AU - Li, Cuiling

AU - Shahabuddin, Mohammed

AU - Wu, Kevin C.W.

AU - Hossain, Md Shahriar A.

AU - Yamauchi, Yusuke

AU - Kim, Jung Ho

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KW - biocompatibility

KW - cytotoxicity

KW - nanoparticles

KW - nanoporous materials

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JO - Chemistry - An Asian Journal

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ER -

Synthesis and Cytotoxicity of Dendritic Platinum Nanoparticles with HEK-293 Cells

Abstract

Bibliographical note

Keywords

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