Synthesis and SAR study of T-type calcium channel blockers. Part II

Jeong Choe Yun; Na Seo Han; Yeon Jung Soo; Hyewhon Rhim; Jungahn Kim; Joon Choo Dong; Yeol Lee Jae

doi:10.1002/ardp.200800079

Synthesis and SAR study of T-type calcium channel blockers. Part II

Jeong Choe Yun
, Na Seo Han
, Yeon Jung Soo
, Hyewhon Rhim
, Jungahn Kim
, Joon Choo Dong
, Yeol Lee Jae

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R ¹, a biphenyl group at R², and a benzyl amido group at R³ in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of 6k (KYS05090).

Original language	English
Pages (from-to)	661-664
Number of pages	4
Journal	Archiv der Pharmazie
Volume	341
Issue number	10
DOIs	https://doi.org/10.1002/ardp.200800079
Publication status	Published - Oct 2008

Keywords

3,4-Dihydroquinazoline
Blockers
SAR study
T-type calcium channel

Access to Document

10.1002/ardp.200800079

Cite this

@article{001907d9722e45a3aa9c340f54a57f49,

title = "Synthesis and SAR study of T-type calcium channel blockers. Part II",

abstract = "3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R 1, a biphenyl group at R2, and a benzyl amido group at R3 in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of 6k (KYS05090).",

keywords = "3,4-Dihydroquinazoline, Blockers, SAR study, T-type calcium channel",

author = "Yun, \{Jeong Choe\} and Han, \{Na Seo\} and Soo, \{Yeon Jung\} and Hyewhon Rhim and Jungahn Kim and Dong, \{Joon Choo\} and Jae, \{Yeol Lee\}",

year = "2008",

month = oct,

doi = "10.1002/ardp.200800079",

language = "English",

volume = "341",

pages = "661--664",

journal = "Archiv der Pharmazie",

issn = "0365-6233",

publisher = "Wiley-VCH Verlag",

number = "10",

}

TY - JOUR

T1 - Synthesis and SAR study of T-type calcium channel blockers. Part II

AU - Yun, Jeong Choe

AU - Han, Na Seo

AU - Soo, Yeon Jung

AU - Rhim, Hyewhon

AU - Kim, Jungahn

AU - Dong, Joon Choo

AU - Jae, Yeol Lee

PY - 2008/10

Y1 - 2008/10

N2 - 3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R 1, a biphenyl group at R2, and a benzyl amido group at R3 in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of 6k (KYS05090).

AB - 3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R 1, a biphenyl group at R2, and a benzyl amido group at R3 in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of 6k (KYS05090).

KW - 3,4-Dihydroquinazoline

KW - Blockers

KW - SAR study

KW - T-type calcium channel

UR - https://www.scopus.com/pages/publications/53549106616

U2 - 10.1002/ardp.200800079

DO - 10.1002/ardp.200800079

M3 - Article

C2 - 18816587

AN - SCOPUS:53549106616

SN - 0365-6233

VL - 341

SP - 661

EP - 664

JO - Archiv der Pharmazie

JF - Archiv der Pharmazie

IS - 10

ER -

Synthesis and SAR study of T-type calcium channel blockers. Part II

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this