Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines

Haena Lee; Yejin Jeon; Hyejin Moon; Eunjoo H. Lee; Tae Hoon Lee; Hakwon Kim

doi:10.3390/ijms24032713

Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines

Haena Lee, Yejin Jeon, Hyejin Moon, Eunjoo H. Lee, Tae Hoon Lee, Hakwon Kim

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

In this study, we designed and synthesized novel 1,4-dialkoxynaphthalene-2-alkyl imidazolium salt (IMS) derivatives containing both 1,4-dialkoxynaphthalene and imidazole, which are well known as pharmacophores. The cytotoxicities of these newly synthesized IMS derivatives were investigated in order to explore the possibility of using them to develop anticancer drugs. It was found that some of the new IMS derivatives showed good cytotoxic activities. In addition, an initial, qualitative structure–activity relationship is presented on the basis of observations of activity changes corresponding to structural changes.

Original language	English
Article number	2713
Journal	International Journal of Molecular Sciences
Volume	24
Issue number	3
DOIs	https://doi.org/10.3390/ijms24032713
Publication status	Published - Feb 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

1,4-dialkoxynaphthalne
CCD-18Co
HT-29
HepG2
cancer
cytotoxicity
imidazole

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms24032713

Cite this

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title = "Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines",

abstract = "In this study, we designed and synthesized novel 1,4-dialkoxynaphthalene-2-alkyl imidazolium salt (IMS) derivatives containing both 1,4-dialkoxynaphthalene and imidazole, which are well known as pharmacophores. The cytotoxicities of these newly synthesized IMS derivatives were investigated in order to explore the possibility of using them to develop anticancer drugs. It was found that some of the new IMS derivatives showed good cytotoxic activities. In addition, an initial, qualitative structure–activity relationship is presented on the basis of observations of activity changes corresponding to structural changes.",

keywords = "1,4-dialkoxynaphthalne, CCD-18Co, HT-29, HepG2, cancer, cytotoxicity, imidazole",

author = "Haena Lee and Yejin Jeon and Hyejin Moon and Lee, {Eunjoo H.} and Lee, {Tae Hoon} and Hakwon Kim",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = feb,

doi = "10.3390/ijms24032713",

language = "English",

volume = "24",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

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T1 - Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines

AU - Lee, Haena

AU - Jeon, Yejin

AU - Moon, Hyejin

AU - Lee, Eunjoo H.

AU - Lee, Tae Hoon

AU - Kim, Hakwon

PY - 2023/2

Y1 - 2023/2

N2 - In this study, we designed and synthesized novel 1,4-dialkoxynaphthalene-2-alkyl imidazolium salt (IMS) derivatives containing both 1,4-dialkoxynaphthalene and imidazole, which are well known as pharmacophores. The cytotoxicities of these newly synthesized IMS derivatives were investigated in order to explore the possibility of using them to develop anticancer drugs. It was found that some of the new IMS derivatives showed good cytotoxic activities. In addition, an initial, qualitative structure–activity relationship is presented on the basis of observations of activity changes corresponding to structural changes.

AB - In this study, we designed and synthesized novel 1,4-dialkoxynaphthalene-2-alkyl imidazolium salt (IMS) derivatives containing both 1,4-dialkoxynaphthalene and imidazole, which are well known as pharmacophores. The cytotoxicities of these newly synthesized IMS derivatives were investigated in order to explore the possibility of using them to develop anticancer drugs. It was found that some of the new IMS derivatives showed good cytotoxic activities. In addition, an initial, qualitative structure–activity relationship is presented on the basis of observations of activity changes corresponding to structural changes.

KW - 1,4-dialkoxynaphthalne

KW - CCD-18Co

KW - HT-29

KW - HepG2

KW - cancer

KW - cytotoxicity

KW - imidazole

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U2 - 10.3390/ijms24032713

DO - 10.3390/ijms24032713

M3 - Article

C2 - 36769036

AN - SCOPUS:85147892765

SN - 1661-6596

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 3

M1 - 2713

ER -

Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines

Abstract

Bibliographical note

Keywords

UN SDGs

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Research Reports from Kyung Hee University Provide New Insights into Cancer (Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines)

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Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Press/Media

Research Reports from Kyung Hee University Provide New Insights into Cancer (Synthesis of 1,4-Dialkoxynaphthalene-Based Imidazolium Salts and Their Cytotoxicity in Cancer Cell Lines)

Cite this