Synthesis of aurones and their inhibitory effects on nitric oxide and PGE 2 productions in LPS-induced RAW 264.7 cells

Seo Young Shin; Min Cheol Shin; Ji Sun Shin; Kyung Tae Lee; Yong Sup Lee

doi:10.1016/j.bmcl.2011.05.117

Synthesis of aurones and their inhibitory effects on nitric oxide and PGE ₂ productions in LPS-induced RAW 264.7 cells

Seo Young Shin, Min Cheol Shin, Ji Sun Shin, Kyung Tae Lee, Yong Sup Lee

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Sulfuretin is one of major constituents of Rhus verniciflua that exerts anti-inflammatory activities. Some of aurones were synthesized as sulfuretin derivatives and evaluated for their abilities to inhibit NO and PGE ₂ production in LPS-induced RAW 264.7 cells in order to reveal the relationship. Of the aurones synthesized in the present study, 2h and 2i, which possess C-6 hydroxyl group in A-ring and methoxy substituents in B-ring, more potently inhibited NO and PGE ₂ production and were less cytotoxic than sulfuretin.

Original language	English
Pages (from-to)	4520-4523
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2011.05.117
Publication status	Published - 1 Aug 2011

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by MEST (2011–0002998).

Keywords

Anti-inflammatory
Aurone
Nitric oxide
Prostaglandin E
Sulfuretin

Access to Document

10.1016/j.bmcl.2011.05.117

Cite this

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title = "Synthesis of aurones and their inhibitory effects on nitric oxide and PGE 2 productions in LPS-induced RAW 264.7 cells",

abstract = "Sulfuretin is one of major constituents of Rhus verniciflua that exerts anti-inflammatory activities. Some of aurones were synthesized as sulfuretin derivatives and evaluated for their abilities to inhibit NO and PGE 2 production in LPS-induced RAW 264.7 cells in order to reveal the relationship. Of the aurones synthesized in the present study, 2h and 2i, which possess C-6 hydroxyl group in A-ring and methoxy substituents in B-ring, more potently inhibited NO and PGE 2 production and were less cytotoxic than sulfuretin.",

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AU - Lee, Kyung Tae

AU - Lee, Yong Sup

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