Systems analysis of alternative splicing and its regulation

Xinshu Xiao, Jae Hyung Lee

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Alternative splicing (AS) has emerged as a key mechanism that accounts for gene expression diversity in metazoan organisms. Splicing is tightly regulated by a repertoire of RNA and protein factors and RNA sequence elements that function in a cooperative manner. Systems-level experimental and computational approaches have been instrumental in establishing comprehensive profiles of transcript variants generated by AS. In addition, systems biology approaches are starting to define how combinatorial splicing regulation shapes the complex splicing phenotypes observed in different tissue types and developmental stages and under different conditions. Here, we review recent progress in these areas.

Original languageEnglish
Pages (from-to)550-565
Number of pages16
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume2
Issue number5
DOIs
Publication statusPublished - Sep 2010

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