Systems Metabolic Engineering of Methanotrophic Bacteria for Biological Conversion of Methane to Value-Added Compounds

Shuqi Guo; Diep Thi Ngoc Nguyen; Tin Hoang Trung Chau; Qiang Fei; Eun Yeol Lee

doi:10.1007/10_2021_184

Systems Metabolic Engineering of Methanotrophic Bacteria for Biological Conversion of Methane to Value-Added Compounds

Shuqi Guo, Diep Thi Ngoc Nguyen, Tin Hoang Trung Chau, Qiang Fei, Eun Yeol Lee

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

7 Citations (Scopus)

Abstract

Methane is considered the carbon source with the highest potential in industrial biotechnology because of its abundance and sustainability. The biological conversion of methane into chemicals or fuels can not only reduce greenhouse gas emissions, but can also substitute edible substrates used in biorefineries. Methanotrophs that can utilize methane as the sole energy and carbon source play a significant role in the ecology of methane. Studies on metabolically-engineered methanotrophs have attracted extensive attention in recent years. In this chapter, the approaches and strategies of methanotrophic cell factory construction are summarized based on synthetic biology tools, systematic manipulation, metabolic modeling, and carbon flux enhancement. Finally, the challenges and opportunities for methane bioconversion by methanotrophs are discussed based on industrial applications.

Original language	English
Title of host publication	Advances in Biochemical Engineering/Biotechnology
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	91-126
Number of pages	36
DOIs	https://doi.org/10.1007/10_2021_184
Publication status	Published - 2022

Publication series

Name	Advances in Biochemical Engineering/Biotechnology
Volume	180
ISSN (Print)	0724-6145
ISSN (Electronic)	1616-8542

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Keywords

Biosynthesis
Metabolic engineering
Methane
Methanotrophs
Synthetic strategy
Value-added compounds

Access to Document

10.1007/10_2021_184

Cite this

Guo, S., Nguyen, D. T. N., Chau, T. H. T., Fei, Q., & Lee, E. Y. (2022). Systems Metabolic Engineering of Methanotrophic Bacteria for Biological Conversion of Methane to Value-Added Compounds. In Advances in Biochemical Engineering/Biotechnology (pp. 91-126). (Advances in Biochemical Engineering/Biotechnology; Vol. 180). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/10_2021_184

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abstract = "Methane is considered the carbon source with the highest potential in industrial biotechnology because of its abundance and sustainability. The biological conversion of methane into chemicals or fuels can not only reduce greenhouse gas emissions, but can also substitute edible substrates used in biorefineries. Methanotrophs that can utilize methane as the sole energy and carbon source play a significant role in the ecology of methane. Studies on metabolically-engineered methanotrophs have attracted extensive attention in recent years. In this chapter, the approaches and strategies of methanotrophic cell factory construction are summarized based on synthetic biology tools, systematic manipulation, metabolic modeling, and carbon flux enhancement. Finally, the challenges and opportunities for methane bioconversion by methanotrophs are discussed based on industrial applications.",

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Guo, S, Nguyen, DTN, Chau, THT, Fei, Q & Lee, EY 2022, Systems Metabolic Engineering of Methanotrophic Bacteria for Biological Conversion of Methane to Value-Added Compounds. in Advances in Biochemical Engineering/Biotechnology. Advances in Biochemical Engineering/Biotechnology, vol. 180, Springer Science and Business Media Deutschland GmbH, pp. 91-126. https://doi.org/10.1007/10_2021_184

Systems Metabolic Engineering of Methanotrophic Bacteria for Biological Conversion of Methane to Value-Added Compounds. / Guo, Shuqi; Nguyen, Diep Thi Ngoc; Chau, Tin Hoang Trung et al.
Advances in Biochemical Engineering/Biotechnology. Springer Science and Business Media Deutschland GmbH, 2022. p. 91-126 (Advances in Biochemical Engineering/Biotechnology; Vol. 180).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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KW - Synthetic strategy

KW - Value-added compounds

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Systems Metabolic Engineering of Methanotrophic Bacteria for Biological Conversion of Methane to Value-Added Compounds

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