Ternary nanofiber matrices composed of PCL/black phosphorus/collagen to enhance osteodifferentiation

Yu Bin Lee, Su Jin Song, Yong Cheol Shin, Yu Jin Jung, Bongju Kim, Moon Sung Kang, Il Keun Kwon, Suong Hyu Hyon, Hyun Uk Lee, Seo Hyun Jung, Dohyung Lim, Dong Wook Han

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Recently, considerable research has been made on the development of bone tissue engineering (BTE) scaffolds to support cellular behaviors. Here, black phosphorus-incorporated poly(ε-caprolactone) and collagen (PCL/BP/Col) nanofiber matrices were designed and their potential as BTE scaffolds were explored. The PCL/BP/Col nanofiber matrices were fabricated successfully by electrospinning, showing that they were suitable for supporting cell growth. The PCL/BP/Col nanofiber matrices could promote not only initial attachment and proliferation, but also osteodifferentiation of preosteoblasts. In conclusion, PCL/BP/Col nanofiber matrices possess excellent biocompatibility and improve osteogenic differentiation. Therefore, the PCL/BP/Col nanofiber matrices can be a promising candidate as a scaffold for BTE.

Original languageEnglish
Pages (from-to)802-810
Number of pages9
JournalJournal of Industrial and Engineering Chemistry
Publication statusPublished - 25 Dec 2019


  • Black phosphorus
  • Bone tissue engineering
  • Collagen
  • Nanofiber matrices
  • Polycaprolactone


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