Tetra-PEG based cell-cartons: Tetra-PEG micro-chamber arrays for cell spheroid formation

H. E. Jeong; Y. J. Heo; S. Chung; A. Sakuma

Tetra-PEG based cell-cartons: Tetra-PEG micro-chamber arrays for cell spheroid formation

H. E. Jeong, Y. J. Heo, S. Chung, A. Sakuma

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Cell implantation has been garnering attention for the treatment of diverse diseases, including diabetes and cancers. Hydrogel-based scaffolds have been employed for obtaining biocompatible microenvironment and immunoisolation. Many types of cell implantation carriers were presented, but they have yet to be realized ideal cellular environment mainly due to has yet cell leakage problems from unwanted degradation and the low cell viabilities. Here, we develop a cell carton based on mechanically-strong hydrogel, tetra-polyethylene glycol (PEG), and characterize tetra-PEG material properties and potential for cell carriers. We envision that the present cell-spheroids carrier can be a cell implantation platform for cell therapy with less cell-loss and high cell-viability.

Original language	English
Title of host publication	MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	582-584
Number of pages	3
ISBN (Electronic)	9780979806483
Publication status	Published - 2015
Event	19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: 25 Oct 2015 → 29 Oct 2015

Publication series

Name	MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference	19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Country/Territory	Korea, Republic of
City	Gyeongju
Period	25/10/15 → 29/10/15

Bibliographical note

Publisher Copyright:
© 15CBMS-0001.

Keywords

3D culture
Cell spheroid
Cell therapy
Tetra-PEG

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Jeong, H. E., Heo, Y. J., Chung, S., & Sakuma, A. (2015). Tetra-PEG based cell-cartons: Tetra-PEG micro-chamber arrays for cell spheroid formation. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 582-584). (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.

Jeong, H. E. ; Heo, Y. J. ; Chung, S. et al. / Tetra-PEG based cell-cartons : Tetra-PEG micro-chamber arrays for cell spheroid formation. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. pp. 582-584 (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

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title = "Tetra-PEG based cell-cartons: Tetra-PEG micro-chamber arrays for cell spheroid formation",

abstract = "Cell implantation has been garnering attention for the treatment of diverse diseases, including diabetes and cancers. Hydrogel-based scaffolds have been employed for obtaining biocompatible microenvironment and immunoisolation. Many types of cell implantation carriers were presented, but they have yet to be realized ideal cellular environment mainly due to has yet cell leakage problems from unwanted degradation and the low cell viabilities. Here, we develop a cell carton based on mechanically-strong hydrogel, tetra-polyethylene glycol (PEG), and characterize tetra-PEG material properties and potential for cell carriers. We envision that the present cell-spheroids carrier can be a cell implantation platform for cell therapy with less cell-loss and high cell-viability.",

keywords = "3D culture, Cell spheroid, Cell therapy, Tetra-PEG",

author = "Jeong, {H. E.} and Heo, {Y. J.} and S. Chung and A. Sakuma",

note = "Publisher Copyright: {\textcopyright} 15CBMS-0001.; 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 ; Conference date: 25-10-2015 Through 29-10-2015",

year = "2015",

language = "English",

series = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

pages = "582--584",

booktitle = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

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Jeong, HE, Heo, YJ, Chung, S & Sakuma, A 2015, Tetra-PEG based cell-cartons: Tetra-PEG micro-chamber arrays for cell spheroid formation. in MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 582-584, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, Gyeongju, Korea, Republic of, 25/10/15.

Tetra-PEG based cell-cartons: Tetra-PEG micro-chamber arrays for cell spheroid formation. / Jeong, H. E.; Heo, Y. J.; Chung, S. et al.
MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. p. 582-584 (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Tetra-PEG based cell-cartons

T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015

AU - Jeong, H. E.

AU - Heo, Y. J.

AU - Chung, S.

AU - Sakuma, A.

PY - 2015

Y1 - 2015

N2 - Cell implantation has been garnering attention for the treatment of diverse diseases, including diabetes and cancers. Hydrogel-based scaffolds have been employed for obtaining biocompatible microenvironment and immunoisolation. Many types of cell implantation carriers were presented, but they have yet to be realized ideal cellular environment mainly due to has yet cell leakage problems from unwanted degradation and the low cell viabilities. Here, we develop a cell carton based on mechanically-strong hydrogel, tetra-polyethylene glycol (PEG), and characterize tetra-PEG material properties and potential for cell carriers. We envision that the present cell-spheroids carrier can be a cell implantation platform for cell therapy with less cell-loss and high cell-viability.

AB - Cell implantation has been garnering attention for the treatment of diverse diseases, including diabetes and cancers. Hydrogel-based scaffolds have been employed for obtaining biocompatible microenvironment and immunoisolation. Many types of cell implantation carriers were presented, but they have yet to be realized ideal cellular environment mainly due to has yet cell leakage problems from unwanted degradation and the low cell viabilities. Here, we develop a cell carton based on mechanically-strong hydrogel, tetra-polyethylene glycol (PEG), and characterize tetra-PEG material properties and potential for cell carriers. We envision that the present cell-spheroids carrier can be a cell implantation platform for cell therapy with less cell-loss and high cell-viability.

KW - 3D culture

KW - Cell spheroid

KW - Cell therapy

KW - Tetra-PEG

UR - http://www.scopus.com/inward/record.url?scp=84983294316&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84983294316

T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

SP - 582

EP - 584

BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

Y2 - 25 October 2015 through 29 October 2015

ER -

Jeong HE, Heo YJ, Chung S, Sakuma A. Tetra-PEG based cell-cartons: Tetra-PEG micro-chamber arrays for cell spheroid formation. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2015. p. 582-584. (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Tetra-PEG based cell-cartons: Tetra-PEG micro-chamber arrays for cell spheroid formation

Abstract

Publication series

Conference

Bibliographical note

Keywords

UN SDGs

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Cite this