TY - JOUR
T1 - The 12 weeks, randomized, double-blinded, placebo-controlled human study to evaluate the effectiveness and safety of KGC deer antlers on the growth of children
AU - Kim, Sang Min
AU - Lee, Jin Yong
AU - Chang, Gyu Tae
AU - Hwangbo, Su Min
AU - Lee, Sun Haeng
N1 - Publisher Copyright:
Copyright © 2022 the Author(s).
PY - 2022/10/28
Y1 - 2022/10/28
N2 - Background: Cervi parvum cornu is a dried section of the young horns of Cervus nippon Temminck, Cervus elaphus Linnaeus, or Cervus canadensis Erxleben. It is a representative yang-tonifying medicine that warms the viscera and bowels, activates the overall physiological function, and has effects such as tonifying kidney yang, replenishing essence and blood, and strengthening muscles and bones. Objective: This clinical study is aimed to evaluate the effectiveness of deer antler extract on child growth. Methods: This clinical trial is designed to be conducted on 100 children aged 3 to 12 years for 12 weeks (Trial registration code: KCT0007386). We will evaluate changes in height, height percentile, standard deviation score of height, weight, body mass index, waist circumference, hip circumference, bone age, predicted adult height estimated by bone age, human growth hormone level, insulin-like growth factor-1 (IGF-1) level, IGF-binding protein-3 (IGFBP-3) level, IGF-1/IGFBP-3 ratio, and estradiol level. Additionally, we also will evaluate the adverse events during the study.
AB - Background: Cervi parvum cornu is a dried section of the young horns of Cervus nippon Temminck, Cervus elaphus Linnaeus, or Cervus canadensis Erxleben. It is a representative yang-tonifying medicine that warms the viscera and bowels, activates the overall physiological function, and has effects such as tonifying kidney yang, replenishing essence and blood, and strengthening muscles and bones. Objective: This clinical study is aimed to evaluate the effectiveness of deer antler extract on child growth. Methods: This clinical trial is designed to be conducted on 100 children aged 3 to 12 years for 12 weeks (Trial registration code: KCT0007386). We will evaluate changes in height, height percentile, standard deviation score of height, weight, body mass index, waist circumference, hip circumference, bone age, predicted adult height estimated by bone age, human growth hormone level, insulin-like growth factor-1 (IGF-1) level, IGF-binding protein-3 (IGFBP-3) level, IGF-1/IGFBP-3 ratio, and estradiol level. Additionally, we also will evaluate the adverse events during the study.
KW - body growth
KW - deer antlers
KW - height
UR - http://www.scopus.com/inward/record.url?scp=85140940934&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000031567
DO - 10.1097/MD.0000000000031567
M3 - Article
C2 - 36316843
AN - SCOPUS:85140940934
SN - 0025-7974
VL - 101
SP - E28397
JO - Medicine (United States)
JF - Medicine (United States)
IS - 43
ER -