The effect of Rhus verniciflua Stokes (RVS) for anti-aging and whitening of skin

Soo Hwa Kim; Hye Sook Seo; Bo Hyoung Jang; Yong Cheol Shin; Seong Gyu Ko

doi:10.1007/s13596-014-0152-8

The effect of Rhus verniciflua Stokes (RVS) for anti-aging and whitening of skin

Soo Hwa Kim
, Hye Sook Seo
, Bo Hyoung Jang
, Yong Cheol Shin
, Seong Gyu Ko

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The purpose of this study is to investigate the effect of new materials from the traditional herbal medicines which induce anti-aging and anti-melanogenesis process of skin in vitro. Among 22 traditional herbal medicines which were tested in this study, Rhus vernciflua stokes (RVS) showed prominent effects for anti-aging and whitening of skin compared to other herbal extracts. In our study, RVS showed the highest elastase inhibitory effect and a higher anti-tyrosinase activity. Pretreatment with RVS significantly inhibited the expressions of UVB-induced MMP-1 protein and mRNA in a dose-dependent manner, and also inhibited the UV-induced activation of extracellular signal regulated kinase (ERK). In whitening, it was found that RVS significantly inhibits melanin biosynthesis in a dose-dependent manner. Moreover, α-MSH-induced increases of microphthalmia-associated transcription factor (MITF) and tyrosinase were significantly inhibited in B16F1 melanoma cells treated with RVS. Therefore, these data suggest that RVS extracts could be a potential agent for the prevention and treatment of skin photoaging and hyperpigmentation.

Original language	English
Pages (from-to)	213-222
Number of pages	10
Journal	Oriental Pharmacy and Experimental Medicine
Volume	14
Issue number	3
DOIs	https://doi.org/10.1007/s13596-014-0152-8
Publication status	Published - Sept 2014

Bibliographical note

Funding Information:
This study was supported by a grant from Korean Medicine R&D project of the Ministry of Health and Welfare (B110043). This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A1A3004797).

Keywords

Anti-aging
Hyperpigmentation
MMP-1
Melanoma
Rhus vernciflua stokes

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10.1007/s13596-014-0152-8

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title = "The effect of Rhus verniciflua Stokes (RVS) for anti-aging and whitening of skin",

abstract = "The purpose of this study is to investigate the effect of new materials from the traditional herbal medicines which induce anti-aging and anti-melanogenesis process of skin in vitro. Among 22 traditional herbal medicines which were tested in this study, Rhus vernciflua stokes (RVS) showed prominent effects for anti-aging and whitening of skin compared to other herbal extracts. In our study, RVS showed the highest elastase inhibitory effect and a higher anti-tyrosinase activity. Pretreatment with RVS significantly inhibited the expressions of UVB-induced MMP-1 protein and mRNA in a dose-dependent manner, and also inhibited the UV-induced activation of extracellular signal regulated kinase (ERK). In whitening, it was found that RVS significantly inhibits melanin biosynthesis in a dose-dependent manner. Moreover, α-MSH-induced increases of microphthalmia-associated transcription factor (MITF) and tyrosinase were significantly inhibited in B16F1 melanoma cells treated with RVS. Therefore, these data suggest that RVS extracts could be a potential agent for the prevention and treatment of skin photoaging and hyperpigmentation.",

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author = "Kim, \{Soo Hwa\} and Seo, \{Hye Sook\} and Jang, \{Bo Hyoung\} and Shin, \{Yong Cheol\} and Ko, \{Seong Gyu\}",

note = "Funding Information: This study was supported by a grant from Korean Medicine R\&D project of the Ministry of Health and Welfare (B110043). This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A1A3004797). ",

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AU - Shin, Yong Cheol

AU - Ko, Seong Gyu

N1 - Funding Information: This study was supported by a grant from Korean Medicine R&D project of the Ministry of Health and Welfare (B110043). This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A1A3004797).

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N2 - The purpose of this study is to investigate the effect of new materials from the traditional herbal medicines which induce anti-aging and anti-melanogenesis process of skin in vitro. Among 22 traditional herbal medicines which were tested in this study, Rhus vernciflua stokes (RVS) showed prominent effects for anti-aging and whitening of skin compared to other herbal extracts. In our study, RVS showed the highest elastase inhibitory effect and a higher anti-tyrosinase activity. Pretreatment with RVS significantly inhibited the expressions of UVB-induced MMP-1 protein and mRNA in a dose-dependent manner, and also inhibited the UV-induced activation of extracellular signal regulated kinase (ERK). In whitening, it was found that RVS significantly inhibits melanin biosynthesis in a dose-dependent manner. Moreover, α-MSH-induced increases of microphthalmia-associated transcription factor (MITF) and tyrosinase were significantly inhibited in B16F1 melanoma cells treated with RVS. Therefore, these data suggest that RVS extracts could be a potential agent for the prevention and treatment of skin photoaging and hyperpigmentation.

AB - The purpose of this study is to investigate the effect of new materials from the traditional herbal medicines which induce anti-aging and anti-melanogenesis process of skin in vitro. Among 22 traditional herbal medicines which were tested in this study, Rhus vernciflua stokes (RVS) showed prominent effects for anti-aging and whitening of skin compared to other herbal extracts. In our study, RVS showed the highest elastase inhibitory effect and a higher anti-tyrosinase activity. Pretreatment with RVS significantly inhibited the expressions of UVB-induced MMP-1 protein and mRNA in a dose-dependent manner, and also inhibited the UV-induced activation of extracellular signal regulated kinase (ERK). In whitening, it was found that RVS significantly inhibits melanin biosynthesis in a dose-dependent manner. Moreover, α-MSH-induced increases of microphthalmia-associated transcription factor (MITF) and tyrosinase were significantly inhibited in B16F1 melanoma cells treated with RVS. Therefore, these data suggest that RVS extracts could be a potential agent for the prevention and treatment of skin photoaging and hyperpigmentation.

KW - Anti-aging

KW - Hyperpigmentation

KW - MMP-1

KW - Melanoma

KW - Rhus vernciflua stokes

UR - https://www.scopus.com/pages/publications/84906544837

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AN - SCOPUS:84906544837

SN - 1598-2386

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JO - Oriental Pharmacy and Experimental Medicine

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ER -

The effect of Rhus verniciflua Stokes (RVS) for anti-aging and whitening of skin

Abstract

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Keywords

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