The effect of surface-modified nano-hydroxyapatite on biocompatibility of poly(ε-caprolactone)/hydroxyapatite nanocomposites

Hong Jae Lee; Sung Eun Kim; Hyung Woo Choi; Chan Woo Kim; Kyung Ja Kim; Sang Cheon Lee

doi:10.1016/j.eurpolymj.2007.02.030

The effect of surface-modified nano-hydroxyapatite on biocompatibility of poly(ε-caprolactone)/hydroxyapatite nanocomposites

Hong Jae Lee, Sung Eun Kim, Hyung Woo Choi, Chan Woo Kim, Kyung Ja Kim, Sang Cheon Lee

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

We describe the effect of surface-modified hydroxyapatite (HAp) nano-crystals on biocompatibility of a new-type nanocomposite consisting of poly(ε-caprolactone) (PCL) and HAp. Surface-modified hydroxyapatite (HAp) nano-crystals were prepared by chemically grafting PCL on HAp surfaces. Time-dependent phase monitoring indicated that PCL surface-grafting contributed to the enhanced dispersion of HAp at nano-level in the PCL solution. The protein adhesion and cell experiments showed that the presence of PCL-grafted HAp nano-crystals in nanocomposites contributed to the enhanced biocompatibility. PCL-grafted HAp in nanocomposites provided more favorable environments for protein adsorption, compared with unmodified HAp. Nanocomposites containing PCL-grafted nanophase HAp showed positive effects on adhesion and proliferation of NIH3T3 fibroblasts.

Original language	English
Pages (from-to)	1602-1608
Number of pages	7
Journal	European Polymer Journal
Volume	43
Issue number	5
DOIs	https://doi.org/10.1016/j.eurpolymj.2007.02.030
Publication status	Published - May 2007

Bibliographical note

Funding Information:
This research was supported by a Grant (Code #: 06K1501-01510) from Center for Nanostructured Materials Technology under 21st Century Frontier R&D Programs of the Ministry of Science and Technology, Korea.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

Grafting
Hydroxyapatite
Nanocomposites
Poly(ε-caprolactone)
Surface modification

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10.1016/j.eurpolymj.2007.02.030

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title = "The effect of surface-modified nano-hydroxyapatite on biocompatibility of poly(ε-caprolactone)/hydroxyapatite nanocomposites",

abstract = "We describe the effect of surface-modified hydroxyapatite (HAp) nano-crystals on biocompatibility of a new-type nanocomposite consisting of poly(ε-caprolactone) (PCL) and HAp. Surface-modified hydroxyapatite (HAp) nano-crystals were prepared by chemically grafting PCL on HAp surfaces. Time-dependent phase monitoring indicated that PCL surface-grafting contributed to the enhanced dispersion of HAp at nano-level in the PCL solution. The protein adhesion and cell experiments showed that the presence of PCL-grafted HAp nano-crystals in nanocomposites contributed to the enhanced biocompatibility. PCL-grafted HAp in nanocomposites provided more favorable environments for protein adsorption, compared with unmodified HAp. Nanocomposites containing PCL-grafted nanophase HAp showed positive effects on adhesion and proliferation of NIH3T3 fibroblasts.",

keywords = "Grafting, Hydroxyapatite, Nanocomposites, Poly(ε-caprolactone), Surface modification",

author = "Lee, {Hong Jae} and Kim, {Sung Eun} and Choi, {Hyung Woo} and Kim, {Chan Woo} and Kim, {Kyung Ja} and Lee, {Sang Cheon}",

note = "Funding Information: This research was supported by a Grant (Code #: 06K1501-01510) from Center for Nanostructured Materials Technology under 21st Century Frontier R&D Programs of the Ministry of Science and Technology, Korea. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

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doi = "10.1016/j.eurpolymj.2007.02.030",

language = "English",

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AU - Kim, Chan Woo

AU - Kim, Kyung Ja

AU - Lee, Sang Cheon

N1 - Funding Information: This research was supported by a Grant (Code #: 06K1501-01510) from Center for Nanostructured Materials Technology under 21st Century Frontier R&D Programs of the Ministry of Science and Technology, Korea. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/5

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N2 - We describe the effect of surface-modified hydroxyapatite (HAp) nano-crystals on biocompatibility of a new-type nanocomposite consisting of poly(ε-caprolactone) (PCL) and HAp. Surface-modified hydroxyapatite (HAp) nano-crystals were prepared by chemically grafting PCL on HAp surfaces. Time-dependent phase monitoring indicated that PCL surface-grafting contributed to the enhanced dispersion of HAp at nano-level in the PCL solution. The protein adhesion and cell experiments showed that the presence of PCL-grafted HAp nano-crystals in nanocomposites contributed to the enhanced biocompatibility. PCL-grafted HAp in nanocomposites provided more favorable environments for protein adsorption, compared with unmodified HAp. Nanocomposites containing PCL-grafted nanophase HAp showed positive effects on adhesion and proliferation of NIH3T3 fibroblasts.

AB - We describe the effect of surface-modified hydroxyapatite (HAp) nano-crystals on biocompatibility of a new-type nanocomposite consisting of poly(ε-caprolactone) (PCL) and HAp. Surface-modified hydroxyapatite (HAp) nano-crystals were prepared by chemically grafting PCL on HAp surfaces. Time-dependent phase monitoring indicated that PCL surface-grafting contributed to the enhanced dispersion of HAp at nano-level in the PCL solution. The protein adhesion and cell experiments showed that the presence of PCL-grafted HAp nano-crystals in nanocomposites contributed to the enhanced biocompatibility. PCL-grafted HAp in nanocomposites provided more favorable environments for protein adsorption, compared with unmodified HAp. Nanocomposites containing PCL-grafted nanophase HAp showed positive effects on adhesion and proliferation of NIH3T3 fibroblasts.

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The effect of surface-modified nano-hydroxyapatite on biocompatibility of poly(ε-caprolactone)/hydroxyapatite nanocomposites

Abstract

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Keywords

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