The effectiveness of Kami Guibi-tang for cognitive impairment patients: A retrospective chart review

Tae Bin Yim; Gyu Ri Jeon; Hye Jin Lee; Kyeong Hwa Lee; Hye Min Heo; Han Gyul Lee; Seungwon Kwon; Seung Yeon Cho; Seong Uk Park; Woo Sang Jung; Sang Kwan Moon; Chang Nam Ko; Jung Mi Park

doi:10.1016/j.heliyon.2023.e23615

The effectiveness of Kami Guibi-tang for cognitive impairment patients: A retrospective chart review

Tae Bin Yim, Gyu Ri Jeon, Hye Jin Lee, Kyeong Hwa Lee, Hye Min Heo, Han Gyul Lee, Seungwon Kwon, Seung Yeon Cho, Seong Uk Park, Woo Sang Jung, Sang Kwan Moon, Chang Nam Ko, Jung Mi Park

Research output: Contribution to journal › Review article › peer-review

Abstract

Background: and Purpose: The number of patients with cognitive impairment is increasing worldwide. Therapeutic drugs that slow disease progression are being developed; however, further research is required. This study investigated the effects of Kami Guibi-tang on patients with various types of cognitive decline. Methods: This study was a single-center, retrospective chart review of patients who visited KyungHee University Hospital at Gangdong from January 2015 to March 2022. The study included participants who took Kami Guibi-tang for more than 90 days and were assessed on the Korean version Mini-Mental State Examination (MMSE-K) scores before and after treatment. Participants who received other liquid herbal medicines during the treatment were excluded. The outcome of interest was changed scores in MMSE-K and Short form of Geriatric Depression Scale (S-GDS). Results: A total of 31 participants were included. The total MMSE-K score significantly increased with time and showed a significant increase at 3 and 9 months compared with baseline. Among the MMSE-K subscores, the orientation subscore showed a significant increase at three months compared with baseline, and the attention and calculation subscore showed a significant increase with time. In addition, four participants with vascular dementia showed a significant increase in the total MMSE-K score over time and a significant increase after 9 months compared with baseline. The S-GDS score in 31 participants showed a significant decrease with time and at all time points compared with baseline. Conclusions: Kami Guibi-tang may improve cognitive function in patients with cognitive decline.

Original language	English
Article number	e23615
Journal	Heliyon
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/j.heliyon.2023.e23615
Publication status	Published - 15 Jan 2024

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Keywords

Alzheimer's disease
Herbal medicine
Kami Guibi-tang
Mild cognitive impairment
Subjective cognitive decline
Vascular dementia

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10.1016/j.heliyon.2023.e23615

Cite this

@article{25189a8e68c449b6b0c096ec07e7fada,

title = "The effectiveness of Kami Guibi-tang for cognitive impairment patients: A retrospective chart review",

abstract = "Background: and Purpose: The number of patients with cognitive impairment is increasing worldwide. Therapeutic drugs that slow disease progression are being developed; however, further research is required. This study investigated the effects of Kami Guibi-tang on patients with various types of cognitive decline. Methods: This study was a single-center, retrospective chart review of patients who visited KyungHee University Hospital at Gangdong from January 2015 to March 2022. The study included participants who took Kami Guibi-tang for more than 90 days and were assessed on the Korean version Mini-Mental State Examination (MMSE-K) scores before and after treatment. Participants who received other liquid herbal medicines during the treatment were excluded. The outcome of interest was changed scores in MMSE-K and Short form of Geriatric Depression Scale (S-GDS). Results: A total of 31 participants were included. The total MMSE-K score significantly increased with time and showed a significant increase at 3 and 9 months compared with baseline. Among the MMSE-K subscores, the orientation subscore showed a significant increase at three months compared with baseline, and the attention and calculation subscore showed a significant increase with time. In addition, four participants with vascular dementia showed a significant increase in the total MMSE-K score over time and a significant increase after 9 months compared with baseline. The S-GDS score in 31 participants showed a significant decrease with time and at all time points compared with baseline. Conclusions: Kami Guibi-tang may improve cognitive function in patients with cognitive decline.",

keywords = "Alzheimer's disease, Herbal medicine, Kami Guibi-tang, Mild cognitive impairment, Subjective cognitive decline, Vascular dementia",

author = "Yim, {Tae Bin} and Jeon, {Gyu Ri} and Lee, {Hye Jin} and Lee, {Kyeong Hwa} and Heo, {Hye Min} and Lee, {Han Gyul} and Seungwon Kwon and Cho, {Seung Yeon} and Park, {Seong Uk} and Jung, {Woo Sang} and Moon, {Sang Kwan} and Ko, {Chang Nam} and Park, {Jung Mi}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2024",

month = jan,

day = "15",

doi = "10.1016/j.heliyon.2023.e23615",

language = "English",

volume = "10",

journal = "Heliyon",

issn = "2405-8440",

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TY - JOUR

T1 - The effectiveness of Kami Guibi-tang for cognitive impairment patients

T2 - A retrospective chart review

AU - Yim, Tae Bin

AU - Jeon, Gyu Ri

AU - Lee, Hye Jin

AU - Lee, Kyeong Hwa

AU - Heo, Hye Min

AU - Lee, Han Gyul

AU - Kwon, Seungwon

AU - Cho, Seung Yeon

AU - Park, Seong Uk

AU - Jung, Woo Sang

AU - Moon, Sang Kwan

AU - Ko, Chang Nam

AU - Park, Jung Mi

PY - 2024/1/15

Y1 - 2024/1/15

N2 - Background: and Purpose: The number of patients with cognitive impairment is increasing worldwide. Therapeutic drugs that slow disease progression are being developed; however, further research is required. This study investigated the effects of Kami Guibi-tang on patients with various types of cognitive decline. Methods: This study was a single-center, retrospective chart review of patients who visited KyungHee University Hospital at Gangdong from January 2015 to March 2022. The study included participants who took Kami Guibi-tang for more than 90 days and were assessed on the Korean version Mini-Mental State Examination (MMSE-K) scores before and after treatment. Participants who received other liquid herbal medicines during the treatment were excluded. The outcome of interest was changed scores in MMSE-K and Short form of Geriatric Depression Scale (S-GDS). Results: A total of 31 participants were included. The total MMSE-K score significantly increased with time and showed a significant increase at 3 and 9 months compared with baseline. Among the MMSE-K subscores, the orientation subscore showed a significant increase at three months compared with baseline, and the attention and calculation subscore showed a significant increase with time. In addition, four participants with vascular dementia showed a significant increase in the total MMSE-K score over time and a significant increase after 9 months compared with baseline. The S-GDS score in 31 participants showed a significant decrease with time and at all time points compared with baseline. Conclusions: Kami Guibi-tang may improve cognitive function in patients with cognitive decline.

AB - Background: and Purpose: The number of patients with cognitive impairment is increasing worldwide. Therapeutic drugs that slow disease progression are being developed; however, further research is required. This study investigated the effects of Kami Guibi-tang on patients with various types of cognitive decline. Methods: This study was a single-center, retrospective chart review of patients who visited KyungHee University Hospital at Gangdong from January 2015 to March 2022. The study included participants who took Kami Guibi-tang for more than 90 days and were assessed on the Korean version Mini-Mental State Examination (MMSE-K) scores before and after treatment. Participants who received other liquid herbal medicines during the treatment were excluded. The outcome of interest was changed scores in MMSE-K and Short form of Geriatric Depression Scale (S-GDS). Results: A total of 31 participants were included. The total MMSE-K score significantly increased with time and showed a significant increase at 3 and 9 months compared with baseline. Among the MMSE-K subscores, the orientation subscore showed a significant increase at three months compared with baseline, and the attention and calculation subscore showed a significant increase with time. In addition, four participants with vascular dementia showed a significant increase in the total MMSE-K score over time and a significant increase after 9 months compared with baseline. The S-GDS score in 31 participants showed a significant decrease with time and at all time points compared with baseline. Conclusions: Kami Guibi-tang may improve cognitive function in patients with cognitive decline.

KW - Alzheimer's disease

KW - Herbal medicine

KW - Kami Guibi-tang

KW - Mild cognitive impairment

KW - Subjective cognitive decline

KW - Vascular dementia

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U2 - 10.1016/j.heliyon.2023.e23615

DO - 10.1016/j.heliyon.2023.e23615

M3 - Review article

AN - SCOPUS:85180089126

SN - 2405-8440

VL - 10

JO - Heliyon

JF - Heliyon

IS - 1

M1 - e23615

ER -

The effectiveness of Kami Guibi-tang for cognitive impairment patients: A retrospective chart review

Abstract

Bibliographical note

Keywords

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Kyung Hee University Hospital at Gangdong Researchers Provide New Study Findings on Science and Technology (The effectiveness of Kami Guibi-tang for cognitive impairment patients: A retrospective chart review)

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The effectiveness of Kami Guibi-tang for cognitive impairment patients: A retrospective chart review

Abstract

Bibliographical note

Keywords

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Kyung Hee University Hospital at Gangdong Researchers Provide New Study Findings on Science and Technology (The effectiveness of Kami Guibi-tang for cognitive impairment patients: A retrospective chart review)

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