Abstract
Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates diverse cellular processes, such as development, reprogramming, differentiation, and proliferation. In regards to these processes, studies of Dot1/DOT1L-dependent H3K79 methylation have mainly focused on the transcriptional regulation of specific genes. Although the gene transcription mediated by Dot1/DOT1L during the cell cycle is not fully understood, H3K79 methylation plays a critical role in the progression of G1 phase, S phase, mitosis, and meiosis. This modification may contribute to the chromatin structure that controls gene expression, replication initiation, DNA damage response, microtubule reorganization, chromosome segregation, and heterochromatin formation. Overall, Dot1/DOT1L is required to maintain genomic and chromosomal stability. This review summarizes the several functions of Dot1/DOT1L and highlights its role in cell cycle regulation.
| Original language | English |
|---|---|
| Pages (from-to) | 726-738 |
| Number of pages | 13 |
| Journal | Cell Cycle |
| Volume | 13 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Mar 2014 |
Bibliographical note
Funding Information:This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2012R1A2A2A01011164 and No.2011-0030072).
Keywords
- Cell cycle
- DOT1L
- Differentiation
- H3K79
- Histone methyltransferase
- Meiosis
- Mitosis
- Proliferation
- Replication
- Senescence
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