The inhibition of nitric oxide synthase enhances PSA-NCAM expression and CREB phosphorylation in the rat hippocampus

Chan Park; Ki Soon Shin; Jong Hoon Ryu; Kyounglan Kang; Junghye Kim; Heekyung Ahn; Youngbuhm Huh

doi:10.1097/00001756-200402090-00003

The inhibition of nitric oxide synthase enhances PSA-NCAM expression and CREB phosphorylation in the rat hippocampus

Chan Park, Ki Soon Shin, Jong Hoon Ryu, Kyounglan Kang, Junghye Kim, Heekyung Ahn, Youngbuhm Huh

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

It is well known that nitric oxide (NO) acts downstream of NMDA receptor activation, which regulates the neural plasticity in the brain. In the present study, the effect of L-NAME, a non-selective nitric oxide synthase (NOS) inhibitor, on neural plasticity in the hippocampus was investigated. L-NAME increased the expression of PSA-NCAM and pCREB in the adult rat hippocampus. The colocalization of PSA-NCAM and pCREB indicates a possible relationship between the two in the granule cell layer in the dentate gyrus. Our results demonstrate that NO, as a subsignal of NMDA receptors, could be involved in the structural plasticity of the granule cell layer in the dentate gyrus by regulating the expression of PSA-NCAM and pCREB in the hippocampus.

Original language	English
Pages (from-to)	231-234
Number of pages	4
Journal	NeuroReport
Volume	15
Issue number	2
DOIs	https://doi.org/10.1097/00001756-200402090-00003
Publication status	Published - 9 Feb 2004

Keywords

Hippocampus
N-Nitro-L-arginine-methyl ester (NAME)
Nitric oxide synthase (NOS)
Phosphorylated cAMP response element binding (pCREB) protein
Polysialylated neural cell adhesion molecule (PSA-NCAM)

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10.1097/00001756-200402090-00003

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title = "The inhibition of nitric oxide synthase enhances PSA-NCAM expression and CREB phosphorylation in the rat hippocampus",

abstract = "It is well known that nitric oxide (NO) acts downstream of NMDA receptor activation, which regulates the neural plasticity in the brain. In the present study, the effect of L-NAME, a non-selective nitric oxide synthase (NOS) inhibitor, on neural plasticity in the hippocampus was investigated. L-NAME increased the expression of PSA-NCAM and pCREB in the adult rat hippocampus. The colocalization of PSA-NCAM and pCREB indicates a possible relationship between the two in the granule cell layer in the dentate gyrus. Our results demonstrate that NO, as a subsignal of NMDA receptors, could be involved in the structural plasticity of the granule cell layer in the dentate gyrus by regulating the expression of PSA-NCAM and pCREB in the hippocampus.",

keywords = "Hippocampus, N-Nitro-L-arginine-methyl ester (NAME), Nitric oxide synthase (NOS), Phosphorylated cAMP response element binding (pCREB) protein, Polysialylated neural cell adhesion molecule (PSA-NCAM)",

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AU - Park, Chan

AU - Shin, Ki Soon

AU - Ryu, Jong Hoon

AU - Kang, Kyounglan

AU - Kim, Junghye

AU - Ahn, Heekyung

AU - Huh, Youngbuhm

PY - 2004/2/9

Y1 - 2004/2/9

N2 - It is well known that nitric oxide (NO) acts downstream of NMDA receptor activation, which regulates the neural plasticity in the brain. In the present study, the effect of L-NAME, a non-selective nitric oxide synthase (NOS) inhibitor, on neural plasticity in the hippocampus was investigated. L-NAME increased the expression of PSA-NCAM and pCREB in the adult rat hippocampus. The colocalization of PSA-NCAM and pCREB indicates a possible relationship between the two in the granule cell layer in the dentate gyrus. Our results demonstrate that NO, as a subsignal of NMDA receptors, could be involved in the structural plasticity of the granule cell layer in the dentate gyrus by regulating the expression of PSA-NCAM and pCREB in the hippocampus.

AB - It is well known that nitric oxide (NO) acts downstream of NMDA receptor activation, which regulates the neural plasticity in the brain. In the present study, the effect of L-NAME, a non-selective nitric oxide synthase (NOS) inhibitor, on neural plasticity in the hippocampus was investigated. L-NAME increased the expression of PSA-NCAM and pCREB in the adult rat hippocampus. The colocalization of PSA-NCAM and pCREB indicates a possible relationship between the two in the granule cell layer in the dentate gyrus. Our results demonstrate that NO, as a subsignal of NMDA receptors, could be involved in the structural plasticity of the granule cell layer in the dentate gyrus by regulating the expression of PSA-NCAM and pCREB in the hippocampus.

KW - Hippocampus

KW - N-Nitro-L-arginine-methyl ester (NAME)

KW - Nitric oxide synthase (NOS)

KW - Phosphorylated cAMP response element binding (pCREB) protein

KW - Polysialylated neural cell adhesion molecule (PSA-NCAM)

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JF - NeuroReport

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ER -

The inhibition of nitric oxide synthase enhances PSA-NCAM expression and CREB phosphorylation in the rat hippocampus

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Keywords

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