TY - JOUR
T1 - The Prognostic Nutritional Index Predicts Survival and Identifies Aggressiveness of Gastric Cancer
AU - Eo, Wan Kyu
AU - Chang, Hye Jung
AU - Suh, Jungho
AU - Ahn, Jin
AU - Shin, Jeong
AU - Hur, Joon Young
AU - Kim, Gou Young
AU - Lee, Sookyung
AU - Park, Sora
AU - Lee, Sanghun
N1 - Publisher Copyright:
Copyright © 2015, Taylor & Francis Group, LLC.
PY - 2015/11/17
Y1 - 2015/11/17
N2 - Nutritional status has been associated with long-term outcomes in cancer patients. The prognostic nutritional index (PNI) is calculated by serum albumin concentration and absolute lymphocyte count, and it may be a surrogate biomarker for nutritional status and possibly predicts overall survival (OS) of gastric cancer. We evaluated the value of the PNI as a predictor for disease-free survival (DFS) in addition to OS in a cohort of 314 gastric cancer patients who underwent curative surgical resection. There were 77 patients in PNI-low group (PNI ≤ 47.3) and 237 patients in PNI-high group (PNI > 47.3). With a median follow-up of 36.5 mo, 5-yr DFS rates in PNI-low group and PNI-high group were 63.5% and 83.6% and 5-yr OS rates in PNI-low group and PNI-high group were 63.5% and 88.4%, respectively (DFS, P < 0.0001; OS, P < 0.0001). In the multivariate analysis, the only predictors for DFS were PNI, tumor-node-metastasis (TNM) stage, and perineural invasion, whereas the only predictors for OS were PNI, age, TNM stage, and perineural invasion. In addition, the PNI was independent of various inflammatory markers. In conclusion, the PNI is an independent prognostic factor for both DFS and OS, and provides additional prognostic information beyond pathologic parameters.
AB - Nutritional status has been associated with long-term outcomes in cancer patients. The prognostic nutritional index (PNI) is calculated by serum albumin concentration and absolute lymphocyte count, and it may be a surrogate biomarker for nutritional status and possibly predicts overall survival (OS) of gastric cancer. We evaluated the value of the PNI as a predictor for disease-free survival (DFS) in addition to OS in a cohort of 314 gastric cancer patients who underwent curative surgical resection. There were 77 patients in PNI-low group (PNI ≤ 47.3) and 237 patients in PNI-high group (PNI > 47.3). With a median follow-up of 36.5 mo, 5-yr DFS rates in PNI-low group and PNI-high group were 63.5% and 83.6% and 5-yr OS rates in PNI-low group and PNI-high group were 63.5% and 88.4%, respectively (DFS, P < 0.0001; OS, P < 0.0001). In the multivariate analysis, the only predictors for DFS were PNI, tumor-node-metastasis (TNM) stage, and perineural invasion, whereas the only predictors for OS were PNI, age, TNM stage, and perineural invasion. In addition, the PNI was independent of various inflammatory markers. In conclusion, the PNI is an independent prognostic factor for both DFS and OS, and provides additional prognostic information beyond pathologic parameters.
UR - http://www.scopus.com/inward/record.url?scp=84948720534&partnerID=8YFLogxK
U2 - 10.1080/01635581.2015.1082112
DO - 10.1080/01635581.2015.1082112
M3 - Article
C2 - 26583916
AN - SCOPUS:84948720534
SN - 0163-5581
VL - 67
SP - 1262
EP - 1269
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 8
ER -
