The role of glutamate in mood disorders: Results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects

Sungho Maeng, Carlos A. Zarate

Research output: Contribution to journalReview articlepeer-review

195 Citations (Scopus)

Abstract

In this article, we first review a study showing that the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine leads to rapid, robust, and relatively sustained antidepressant effects in patients with treatment-resistant major depression. We then discuss our hypothesis that the therapeutic effects of monoaminergic antidepressants and ketamine may be mediated by increased AMPA-to-NMDA glutamate receptor throughput in critical neuronal circuits. We hypothesize that ketamine directly mediates this throughput, whereas monoaminergic antidepressants work indirectly and gradually; this may explain, in part, the lag of onset of several weeks to months that is observed with traditional antidepressants.

Original languageEnglish
Pages (from-to)467-474
Number of pages8
JournalCurrent Psychiatry Reports
Volume9
Issue number6
DOIs
Publication statusPublished - Dec 2007

Fingerprint

Dive into the research topics of 'The role of glutamate in mood disorders: Results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects'. Together they form a unique fingerprint.

Cite this