Abstract
Sodium picosulfate, a laxative, was biotransformed to 4,4'-dihydroxydiphenyl-(2 pyridyl)-methane by intestinal flora that produced a novel sulfotransferase (not sulfatase). The biotransformation was activated by adding phenolic compounds such as phenol, acetaminophen and flavonoids. The enzyme activity related to this biotransformation was the highest in the contents of the caecum region of the intestine. The enzyme activity was 3.0 μmole/hr/g wet feces in humans and 0.75 in rats (pH 8.0). The optimal pH was 9.0.
| Original language | English |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | Japanese Journal of Pharmacology |
| Volume | 59 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1992 |
Keywords
- Biotransformation
- Intestinal flora
- Laxative
- Picosulfate
- Sulfotransferase
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