The suppressive effects of Cinnamomi Cortex and its phytocompound coumarin on oxaliplatin-induced neuropathic cold allodynia in rats

Changmin Kim, Ji Hwan Lee, Woojin Kim, Dongxing Li, Yangseok Kim, Kyungjin Lee, Sun Kwang Kim

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Oxaliplatin, a chemotherapy drug, induces acute peripheral neuropathy characterized by cold allodynia, spinal glial activation and increased levels of pro-inflammatory cytokines. Herein, we determined whether Cinnamomi Cortex (C. Cortex), a widely used medicinal herb in East Asia for cold-related diseases, could attenuate oxaliplatin-induced cold allodynia in rats and the mechanisms involved. A single oxaliplatin injection (6 mg/kg, i.p.) induced significant cold allodynia signs based on tail immersion tests using cold water (4°C). Daily oral administration of water extract of C. Cortex (WECC) (100, 200, and 400 mg/kg) for five consecutive days following an oxaliplatin injection dose-dependently alleviated cold allodynia with only a slight difference in efficacies between the middle dose at 200 mg/kg and the highest dose at 400 mg/kg. WECC at 200 mg/kg significantly suppressed the activation of astrocytes and microglia and decreased the expression levels of IL-1β and TNF in the spinal cord after injection with oxaliplatin. Furthermore, oral administration of coumarin (10 mg/kg), a major phytocompound of C. Cortex, markedly reduced cold allodynia. These results indicate that C. Cortex has a potent anti-allodynic effect in oxaliplatin-injected rats through inhibiting spinal glial cells and pro-inflammatory cytokines. We also suggest that coumarin might play a role in the anti-allodynic effect of C. Cortex.

Original languageEnglish
Article number1253
JournalMolecules
Volume21
Issue number9
DOIs
Publication statusPublished - 1 Sept 2016

Bibliographical note

Publisher Copyright:
© 2016 by the authors; licensee MDPI.

Keywords

  • Cinnamomi Cortex
  • Cold allodynia
  • Coumarin
  • Glia
  • Pro-inflammatory cytokines
  • Spinal cord

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