TMEM126A, a CD137 ligand binding protein, couples with the TLR4 signal transduction pathway in macrophages

Eun Cheol Kim; Ji Hoi Moon; Sang W. Kang; Byungsuk Kwon; Hyeon Woo Lee

doi:10.1016/j.molimm.2014.12.001

TMEM126A, a CD137 ligand binding protein, couples with the TLR4 signal transduction pathway in macrophages

Eun Cheol Kim, Ji Hoi Moon, Sang W. Kang, Byungsuk Kwon, Hyeon Woo Lee

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We showed previously that a novel protein, transmembrane protein 126A (TMEM126A), binds to CD137 ligand (CD137L, 4-1BBL) and couples with its reverse signals in macrophages. Here, we present data showing that TMEM126A relays TLR4 signaling. Thus, up-regulation of CD54 (ICAM-1), MHC II, CD86 and CD40 expression in response to TLR4 activation was diminished in TMEM126A-deficient macrophages. Moreover in TMEM126A-deficient RAW264.7 cells, LPS/TLR4-induced late-phase JNK/SAPK and IRF-3 phosphorylation was abolished. These findings indicate that TMEM126A contributes to the TLR4 signal up-regulating the expression of genes whose products are involved in antigen presentation.

Original language	English
Pages (from-to)	244-251
Number of pages	8
Journal	Molecular Immunology
Volume	64
Issue number	2
DOIs	https://doi.org/10.1016/j.molimm.2014.12.001
Publication status	Published - 1 Apr 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd.

Keywords

Antigen presenting
CD137L
Innate immunity
TMEM126A
TRL4

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10.1016/j.molimm.2014.12.001

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title = "TMEM126A, a CD137 ligand binding protein, couples with the TLR4 signal transduction pathway in macrophages",

abstract = "We showed previously that a novel protein, transmembrane protein 126A (TMEM126A), binds to CD137 ligand (CD137L, 4-1BBL) and couples with its reverse signals in macrophages. Here, we present data showing that TMEM126A relays TLR4 signaling. Thus, up-regulation of CD54 (ICAM-1), MHC II, CD86 and CD40 expression in response to TLR4 activation was diminished in TMEM126A-deficient macrophages. Moreover in TMEM126A-deficient RAW264.7 cells, LPS/TLR4-induced late-phase JNK/SAPK and IRF-3 phosphorylation was abolished. These findings indicate that TMEM126A contributes to the TLR4 signal up-regulating the expression of genes whose products are involved in antigen presentation.",

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author = "Kim, {Eun Cheol} and Moon, {Ji Hoi} and Kang, {Sang W.} and Byungsuk Kwon and Lee, {Hyeon Woo}",

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T1 - TMEM126A, a CD137 ligand binding protein, couples with the TLR4 signal transduction pathway in macrophages

AU - Kim, Eun Cheol

AU - Moon, Ji Hoi

AU - Kang, Sang W.

AU - Kwon, Byungsuk

AU - Lee, Hyeon Woo

PY - 2015/4/1

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AB - We showed previously that a novel protein, transmembrane protein 126A (TMEM126A), binds to CD137 ligand (CD137L, 4-1BBL) and couples with its reverse signals in macrophages. Here, we present data showing that TMEM126A relays TLR4 signaling. Thus, up-regulation of CD54 (ICAM-1), MHC II, CD86 and CD40 expression in response to TLR4 activation was diminished in TMEM126A-deficient macrophages. Moreover in TMEM126A-deficient RAW264.7 cells, LPS/TLR4-induced late-phase JNK/SAPK and IRF-3 phosphorylation was abolished. These findings indicate that TMEM126A contributes to the TLR4 signal up-regulating the expression of genes whose products are involved in antigen presentation.

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KW - Innate immunity

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KW - TRL4

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JO - Molecular Immunology

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ER -

TMEM126A, a CD137 ligand binding protein, couples with the TLR4 signal transduction pathway in macrophages

Abstract

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Keywords

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