@inproceedings{8eb34d5d7f3d4e09bdbe661620a93df1,
title = "'Transmural flow imposes shear stress on smooth muscle cells in the artery wall?'",
abstract = "Smooth muscle cells in culture have been shown to be sensitive to fluid shear stress. Smooth muscle cells in vivo may be exposed to shear stress associated with transmural volume flow. To investigate this hypothesis we combine a phenomenological theory of flow in deformable, porous media with a pore theory to model transmural volume flow in arteries and to calculate the shear stress on the pore walls (smooth muscle cell surface). The model accurately describes the dependence of hydraulic conductivity, porosity and albumin partition coefficient on the transmural pressure gradient. It predicts pore wall shear stresses ranging from 0.1N/m2 to 0.3N/m2 for transmural pressures between 70 and 180 mmHg. These levels of shear stress will stimulate endothelial cells and may also affect smooth muscle cells.",
author = "Kim, {Woo Sik} and Tarbell, {John M.}",
note = "Copyright: Copyright 2004 Elsevier B.V., All rights reserved.; Winter Annual Meeting of the American Society of Mechanical Engineers ; Conference date: 01-12-1991 Through 06-12-1991",
year = "1991",
language = "English",
isbn = "0791808890",
series = "American Society of Mechanical Engineers, Bioengineering Division (Publication) BED",
publisher = "Publ by ASME",
pages = "429--432",
booktitle = "1991 Advances in Bioengineering",
}