Transplantation of mouse embryo fibroblasts: An approach to study the physiological pathways linking the suprachiasmatic nucleus and peripheral clocks

Sehyung Cho; Irene Yujnovsky; Masao Doi; Paolo Sassone-Corsi

Transplantation of mouse embryo fibroblasts: An approach to study the physiological pathways linking the suprachiasmatic nucleus and peripheral clocks

Sehyung Cho
, Irene Yujnovsky
, Masao Doi
, Paolo Sassone-Corsi

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

One of the unresolved issues in the field of circadian biology is dissection of the communication pathways between central and peripheral oscillators. We have developed an experimental procedure in which an implant of mouse embryo fibroblasts of a specific genotype can be successfully grafted into a host animal of a different genotype. This methodology provides an excellent tool to study how peripheral clocks are entrained under various physiological settings and the contribution of individual signaling effectors in this process.

Original language	English
Article number	23
Pages (from-to)	469-478
Number of pages	10
Journal	Methods in Enzymology
Volume	393
Publication status	Published - 2005

Cite this

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title = "Transplantation of mouse embryo fibroblasts: An approach to study the physiological pathways linking the suprachiasmatic nucleus and peripheral clocks",

abstract = "One of the unresolved issues in the field of circadian biology is dissection of the communication pathways between central and peripheral oscillators. We have developed an experimental procedure in which an implant of mouse embryo fibroblasts of a specific genotype can be successfully grafted into a host animal of a different genotype. This methodology provides an excellent tool to study how peripheral clocks are entrained under various physiological settings and the contribution of individual signaling effectors in this process.",

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T2 - An approach to study the physiological pathways linking the suprachiasmatic nucleus and peripheral clocks

AU - Cho, Sehyung

AU - Yujnovsky, Irene

AU - Doi, Masao

AU - Sassone-Corsi, Paolo

PY - 2005

Y1 - 2005

N2 - One of the unresolved issues in the field of circadian biology is dissection of the communication pathways between central and peripheral oscillators. We have developed an experimental procedure in which an implant of mouse embryo fibroblasts of a specific genotype can be successfully grafted into a host animal of a different genotype. This methodology provides an excellent tool to study how peripheral clocks are entrained under various physiological settings and the contribution of individual signaling effectors in this process.

AB - One of the unresolved issues in the field of circadian biology is dissection of the communication pathways between central and peripheral oscillators. We have developed an experimental procedure in which an implant of mouse embryo fibroblasts of a specific genotype can be successfully grafted into a host animal of a different genotype. This methodology provides an excellent tool to study how peripheral clocks are entrained under various physiological settings and the contribution of individual signaling effectors in this process.

UR - https://www.scopus.com/pages/publications/16844379098

M3 - Article

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AN - SCOPUS:16844379098

SN - 0076-6879

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EP - 478

JO - Methods in Enzymology

JF - Methods in Enzymology

M1 - 23

ER -

Transplantation of mouse embryo fibroblasts: An approach to study the physiological pathways linking the suprachiasmatic nucleus and peripheral clocks

Abstract

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