TY - JOUR
T1 - Trend of nontuberculous mycobacteria species and minimal inhibitory concentration in a referral laboratory in Korea from 2013 to 2019
AU - Kim, Young Jin
AU - Kim, Seungmo
AU - Ham, Heejung
AU - Yu, Sarah
AU - Choo, Hyeon Ju
AU - Kim, Hwi Jun
AU - Heo, Ryeun
AU - Choi, Gyeongsik
AU - Kim, Soul hee
AU - Lee, Hee Joo
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2024/2
Y1 - 2024/2
N2 - Background: This study investigated the trends of nontuberculous mycobacterial (NTM) isolates and the minimal inhibitory concentrations (MIC) of antimicrobial agents in Korea. Methods: Data from 2013 to 2019 were collected from 69 medical institutions through 12 branches of the Korean Institute of Tuberculosis. NTM identification was conducted using the Advansure Mycobacteria Genoblot assay. The MIC of antibiotics against NTM species were measured using the broth microdilution method according to the Clinical and Laboratory Standards Institute guidelines. Results: Over seven years, 86,194 NTM identifications were requested, with an annual increase from 8034 in 2013–17,229 in 2019. The most frequently identified NTM species were M. intracellulare (33,467; 47.3%) and M. avium (19,818; 27.2%), followed by M. abscessus (6858; 9.4%) and M. massiliense (3156; 4.3%). Regarding the antimicrobial agents, imipenem exhibited the greatest difference in MIC between M. intracellulare and M. avium, whereas clarithromycin showed the most significant difference between M. abscessus and M. massiliense. No notable changes were observed in the annual MIC distribution of most antibacterial agents, except for clarithromycin in M. abscessus. Conclusions: The prevalence of NTM in Korea is gradually increasing, and follow-up studies on NTM isolates identified as the causative agents of infection are needed.
AB - Background: This study investigated the trends of nontuberculous mycobacterial (NTM) isolates and the minimal inhibitory concentrations (MIC) of antimicrobial agents in Korea. Methods: Data from 2013 to 2019 were collected from 69 medical institutions through 12 branches of the Korean Institute of Tuberculosis. NTM identification was conducted using the Advansure Mycobacteria Genoblot assay. The MIC of antibiotics against NTM species were measured using the broth microdilution method according to the Clinical and Laboratory Standards Institute guidelines. Results: Over seven years, 86,194 NTM identifications were requested, with an annual increase from 8034 in 2013–17,229 in 2019. The most frequently identified NTM species were M. intracellulare (33,467; 47.3%) and M. avium (19,818; 27.2%), followed by M. abscessus (6858; 9.4%) and M. massiliense (3156; 4.3%). Regarding the antimicrobial agents, imipenem exhibited the greatest difference in MIC between M. intracellulare and M. avium, whereas clarithromycin showed the most significant difference between M. abscessus and M. massiliense. No notable changes were observed in the annual MIC distribution of most antibacterial agents, except for clarithromycin in M. abscessus. Conclusions: The prevalence of NTM in Korea is gradually increasing, and follow-up studies on NTM isolates identified as the causative agents of infection are needed.
KW - Antimicrobial agents
KW - Korea
KW - Minimal inhibitory concentrations
KW - Nontuberculous mycobacteria
KW - Trends
UR - http://www.scopus.com/inward/record.url?scp=85181946325&partnerID=8YFLogxK
U2 - 10.1016/j.jiph.2023.11.028
DO - 10.1016/j.jiph.2023.11.028
M3 - Article
C2 - 38113818
AN - SCOPUS:85181946325
SN - 1876-0341
VL - 17
SP - 212
EP - 216
JO - Journal of Infection and Public Health
JF - Journal of Infection and Public Health
IS - 2
ER -