Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease

Audrey Duarte; Satoru Hayasaka; Antao Du; Norbert Schuff; Geon Ho Jahng; Joel Kramer; Bruce Miller; Michael Weiner

doi:10.1016/j.neulet.2006.07.029

Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease

Audrey Duarte, Satoru Hayasaka, Antao Du, Norbert Schuff, Geon Ho Jahng, Joel Kramer, Bruce Miller, Michael Weiner

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

In Alzheimer's disease (AD), atrophy negatively impacts cognition while in healthy adults, inverse relationships between brain volume and cognition may occur. We investigated correlations between gray matter volume and cognition in elderly controls, AD and mild cognitive impairment (MCI) patients with memory and executive deficits. AD demonstrated substantial loss in temporal, parietal and frontal regions while MCI exhibited moderate volume loss in temporal and frontal regions. In controls, memory and executive function were negatively correlated with frontal regions, while in AD, memory was positively correlated with temporal and frontal gyri, and executive function with frontal regions. The combination of the two patterns may explain the lack of correlations in MCI. Developmental versus pathological contributions to these relationships are discussed.

Original language	English
Pages (from-to)	60-65
Number of pages	6
Journal	Neuroscience Letters
Volume	406
Issue number	1-2
DOIs	https://doi.org/10.1016/j.neulet.2006.07.029
Publication status	Published - 2 Oct 2006

Bibliographical note

Funding Information:
This research was supported by NIA grant 2R01AG10897-18.

Keywords

Alzheimer's
Correlation
Executive
Memory
Mild cognitive impairment
Volumetry

Access to Document

10.1016/j.neulet.2006.07.029

Cite this

@article{ee607803b4da42a2a4f4e52d80be3c2a,

title = "Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease",

abstract = "In Alzheimer's disease (AD), atrophy negatively impacts cognition while in healthy adults, inverse relationships between brain volume and cognition may occur. We investigated correlations between gray matter volume and cognition in elderly controls, AD and mild cognitive impairment (MCI) patients with memory and executive deficits. AD demonstrated substantial loss in temporal, parietal and frontal regions while MCI exhibited moderate volume loss in temporal and frontal regions. In controls, memory and executive function were negatively correlated with frontal regions, while in AD, memory was positively correlated with temporal and frontal gyri, and executive function with frontal regions. The combination of the two patterns may explain the lack of correlations in MCI. Developmental versus pathological contributions to these relationships are discussed.",

keywords = "Alzheimer's, Correlation, Executive, Memory, Mild cognitive impairment, Volumetry",

author = "Audrey Duarte and Satoru Hayasaka and Antao Du and Norbert Schuff and Jahng, {Geon Ho} and Joel Kramer and Bruce Miller and Michael Weiner",

note = "Funding Information: This research was supported by NIA grant 2R01AG10897-18. ",

year = "2006",

month = oct,

day = "2",

doi = "10.1016/j.neulet.2006.07.029",

language = "English",

volume = "406",

pages = "60--65",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease

AU - Duarte, Audrey

AU - Hayasaka, Satoru

AU - Du, Antao

AU - Schuff, Norbert

AU - Jahng, Geon Ho

AU - Kramer, Joel

AU - Miller, Bruce

AU - Weiner, Michael

N1 - Funding Information: This research was supported by NIA grant 2R01AG10897-18.

PY - 2006/10/2

Y1 - 2006/10/2

N2 - In Alzheimer's disease (AD), atrophy negatively impacts cognition while in healthy adults, inverse relationships between brain volume and cognition may occur. We investigated correlations between gray matter volume and cognition in elderly controls, AD and mild cognitive impairment (MCI) patients with memory and executive deficits. AD demonstrated substantial loss in temporal, parietal and frontal regions while MCI exhibited moderate volume loss in temporal and frontal regions. In controls, memory and executive function were negatively correlated with frontal regions, while in AD, memory was positively correlated with temporal and frontal gyri, and executive function with frontal regions. The combination of the two patterns may explain the lack of correlations in MCI. Developmental versus pathological contributions to these relationships are discussed.

AB - In Alzheimer's disease (AD), atrophy negatively impacts cognition while in healthy adults, inverse relationships between brain volume and cognition may occur. We investigated correlations between gray matter volume and cognition in elderly controls, AD and mild cognitive impairment (MCI) patients with memory and executive deficits. AD demonstrated substantial loss in temporal, parietal and frontal regions while MCI exhibited moderate volume loss in temporal and frontal regions. In controls, memory and executive function were negatively correlated with frontal regions, while in AD, memory was positively correlated with temporal and frontal gyri, and executive function with frontal regions. The combination of the two patterns may explain the lack of correlations in MCI. Developmental versus pathological contributions to these relationships are discussed.

KW - Alzheimer's

KW - Correlation

KW - Executive

KW - Memory

KW - Mild cognitive impairment

KW - Volumetry

UR - http://www.scopus.com/inward/record.url?scp=33747793974&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2006.07.029

DO - 10.1016/j.neulet.2006.07.029

M3 - Article

C2 - 16904823

AN - SCOPUS:33747793974

SN - 0304-3940

VL - 406

SP - 60

EP - 65

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this