Wireless, Soft Sensors of Skin Hydration with Designs Optimized for Rapid, Accurate Diagnostics of Dermatological Health

Jaeho Shin; Heling Wang; Kyeongha Kwon; Diana Ostojich; Zach Christiansen; Jaime Berkovich; Yoonseok Park; Zhengwei Li; Geumbee Lee; Rania Nasif; Ted S. Chung; Chun Ju Su; Jaeman Lim; Hitoki Kubota; Akihiko Ikoma; Yi An Lu; Derrick H. Lin; Shuai Xu; Anthony Banks; Jan Kai Chang; John A. Rogers

doi:10.1002/adhm.202202021

Wireless, Soft Sensors of Skin Hydration with Designs Optimized for Rapid, Accurate Diagnostics of Dermatological Health

Jaeho Shin, Heling Wang, Kyeongha Kwon, Diana Ostojich, Zach Christiansen, Jaime Berkovich, Yoonseok Park, Zhengwei Li, Geumbee Lee, Rania Nasif, Ted S. Chung, Chun Ju Su, Jaeman Lim, Hitoki Kubota, Akihiko Ikoma, Yi An Lu, Derrick H. Lin, Shuai Xu, Anthony Banks, Jan Kai ChangJohn A. Rogers

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Accurate measurements of skin hydration are of great interest to dermatological science and clinical practice. This parameter serves as a relevant surrogate of skin barrier function, a key representative benchmark for overall skin health. The skin hydration sensor (SHS) is a soft, skin-interfaced wireless system that exploits a thermal measurement method, as an alternative to conventional impedance-based hand-held probes. This study presents multiple strategies for maximizing the sensitivity and reliability of this previously reported SHS platform. An in-depth analysis of the thermal physics of the measurement process serves as the basis for structural optimizations of the electronics and the interface to the skin. Additional engineering advances eliminate variabilities associated with manual use of the device and with protocols for the measurement. The cumulative effect is an improvement in sensitivity by 135% and in repeatability by 36% over previously reported results. Pilot trials on more than 200 patients in a dermatology clinic validate the practical utility of the sensor for fast, reliable measurements.

Original language	English
Article number	2202021
Journal	Advanced healthcare materials
Volume	12
Issue number	4
DOIs	https://doi.org/10.1002/adhm.202202021
Publication status	Published - 6 Feb 2023

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.

Keywords

biomedical devices
diagnostics
flexible electronics
health monitoring
wireless electronics

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10.1002/adhm.202202021

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Shin, J., Wang, H., Kwon, K., Ostojich, D., Christiansen, Z., Berkovich, J., Park, Y., Li, Z., Lee, G., Nasif, R., Chung, T. S., Su, C. J., Lim, J., Kubota, H., Ikoma, A., Lu, Y. A., Lin, D. H., Xu, S., Banks, A., ... Rogers, J. A. (2023). Wireless, Soft Sensors of Skin Hydration with Designs Optimized for Rapid, Accurate Diagnostics of Dermatological Health. Advanced healthcare materials, 12(4), Article 2202021. https://doi.org/10.1002/adhm.202202021

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abstract = "Accurate measurements of skin hydration are of great interest to dermatological science and clinical practice. This parameter serves as a relevant surrogate of skin barrier function, a key representative benchmark for overall skin health. The skin hydration sensor (SHS) is a soft, skin-interfaced wireless system that exploits a thermal measurement method, as an alternative to conventional impedance-based hand-held probes. This study presents multiple strategies for maximizing the sensitivity and reliability of this previously reported SHS platform. An in-depth analysis of the thermal physics of the measurement process serves as the basis for structural optimizations of the electronics and the interface to the skin. Additional engineering advances eliminate variabilities associated with manual use of the device and with protocols for the measurement. The cumulative effect is an improvement in sensitivity by 135% and in repeatability by 36% over previously reported results. Pilot trials on more than 200 patients in a dermatology clinic validate the practical utility of the sensor for fast, reliable measurements.",

keywords = "biomedical devices, diagnostics, flexible electronics, health monitoring, wireless electronics",

author = "Jaeho Shin and Heling Wang and Kyeongha Kwon and Diana Ostojich and Zach Christiansen and Jaime Berkovich and Yoonseok Park and Zhengwei Li and Geumbee Lee and Rania Nasif and Chung, {Ted S.} and Su, {Chun Ju} and Jaeman Lim and Hitoki Kubota and Akihiko Ikoma and Lu, {Yi An} and Lin, {Derrick H.} and Shuai Xu and Anthony Banks and Chang, {Jan Kai} and Rogers, {John A.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.",

year = "2023",

month = feb,

day = "6",

doi = "10.1002/adhm.202202021",

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Shin, J, Wang, H, Kwon, K, Ostojich, D, Christiansen, Z, Berkovich, J, Park, Y, Li, Z, Lee, G, Nasif, R, Chung, TS, Su, CJ, Lim, J, Kubota, H, Ikoma, A, Lu, YA, Lin, DH, Xu, S, Banks, A, Chang, JK & Rogers, JA 2023, 'Wireless, Soft Sensors of Skin Hydration with Designs Optimized for Rapid, Accurate Diagnostics of Dermatological Health', Advanced healthcare materials, vol. 12, no. 4, 2202021. https://doi.org/10.1002/adhm.202202021

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AU - Wang, Heling

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AU - Ostojich, Diana

AU - Christiansen, Zach

AU - Berkovich, Jaime

AU - Park, Yoonseok

AU - Li, Zhengwei

AU - Lee, Geumbee

AU - Nasif, Rania

AU - Chung, Ted S.

AU - Su, Chun Ju

AU - Lim, Jaeman

AU - Kubota, Hitoki

AU - Ikoma, Akihiko

AU - Lu, Yi An

AU - Lin, Derrick H.

AU - Xu, Shuai

AU - Banks, Anthony

AU - Chang, Jan Kai

AU - Rogers, John A.

PY - 2023/2/6

Y1 - 2023/2/6

N2 - Accurate measurements of skin hydration are of great interest to dermatological science and clinical practice. This parameter serves as a relevant surrogate of skin barrier function, a key representative benchmark for overall skin health. The skin hydration sensor (SHS) is a soft, skin-interfaced wireless system that exploits a thermal measurement method, as an alternative to conventional impedance-based hand-held probes. This study presents multiple strategies for maximizing the sensitivity and reliability of this previously reported SHS platform. An in-depth analysis of the thermal physics of the measurement process serves as the basis for structural optimizations of the electronics and the interface to the skin. Additional engineering advances eliminate variabilities associated with manual use of the device and with protocols for the measurement. The cumulative effect is an improvement in sensitivity by 135% and in repeatability by 36% over previously reported results. Pilot trials on more than 200 patients in a dermatology clinic validate the practical utility of the sensor for fast, reliable measurements.

AB - Accurate measurements of skin hydration are of great interest to dermatological science and clinical practice. This parameter serves as a relevant surrogate of skin barrier function, a key representative benchmark for overall skin health. The skin hydration sensor (SHS) is a soft, skin-interfaced wireless system that exploits a thermal measurement method, as an alternative to conventional impedance-based hand-held probes. This study presents multiple strategies for maximizing the sensitivity and reliability of this previously reported SHS platform. An in-depth analysis of the thermal physics of the measurement process serves as the basis for structural optimizations of the electronics and the interface to the skin. Additional engineering advances eliminate variabilities associated with manual use of the device and with protocols for the measurement. The cumulative effect is an improvement in sensitivity by 135% and in repeatability by 36% over previously reported results. Pilot trials on more than 200 patients in a dermatology clinic validate the practical utility of the sensor for fast, reliable measurements.

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Wireless, Soft Sensors of Skin Hydration with Designs Optimized for Rapid, Accurate Diagnostics of Dermatological Health

Abstract

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Keywords

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